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ABSITE Fiser Hematology Ch.2 Questions and Answers
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Identify the five main steps of platelet aggregation.  :-- 1. Platelet adhesion  2. Platelet shape change and adherence to exposed subendothelial collagen  3. Granule release (ADP, TXA2)  4. Recruitment of other platelets  5. Formation of hemostatic plug What is the primary inc...

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  • August 28, 2024
  • 34
  • 2024/2025
  • Exam (elaborations)
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  • absite fiser hematology ch2 questions and answers

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Elscores: Aug. 27, 24- 2024/2025

ABSITE Fiser Hematology Ch.2
Questions and Answers
Identify the five main steps of platelet aggregation.


 :-- 1. Platelet adhesion

 2. Platelet shape change and adherence to exposed subendothelial collagen

 3. Granule release (ADP, TXA2)

 4. Recruitment of other platelets

 5. Formation of hemostatic plug




What is the primary inciting event for thrombus formation?


 :-- Exposure of subendothelial collagen




What are the three initial responses to vascular injury?


 :-- 1. Vascular vasoconstriction

2. Platelet adhesion

3. Thrombin generation




Identify the 6 main steps of the INTRINSIC pathway.


 :-- 1. Collagen is exposed to prekallikrein, HMW kininogen, and factor XII

2. Factor XI activated

3. Factor IX activated



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, 2
Elscores: Aug. 27, 24- 2024/2025

4. Factor IX + Factor VIII activates Factor X

5. Factor X + Factor V converts prothrombin to thrombin

6. Thrombin converts fibrinogen to fibrin




Identify the 4 main steps of the EXTRINSIC pathway.


 :-- 1. Injured cells release tissue factor

2. Tissue factor + Factor VII activates Factor X

3. Factor X + Factor V converts prothrombin to thrombin

4. Thrombin converts fibrinogen to fibrin




Identify the 5 components of the prothrombin complex.


 :-- 1. Factor X

2. Factor V

3. Platelet factor 3

4. Prothrombin

5. Ca2+




On what surface does the prothrombin complex form? What reaction does it catalyze?


 :-- - Prothrombin complex forms on platelet surface

- Catalyzes the formation of THROMBIN




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Elscores: Aug. 27, 24- 2024/2025

What is the significance of Factor X relative to the intrinsic and extrinsic pathway?


 :-- Factor X is the convergence point of the intrinsic and extrinsic pathways




What is the function of tissue factor pathway inhibitor?


 :-- TFPI inhibits Factor X




What is the function of fibrin (3 parts)?


 :-- - Fibrin links platelets together by binding GpIIa/IIIb molecules

--> Forms platelet plug

--> Hemostasis




What is the primary function of Factor XIII?


 :-- Helps crosslink fibrin




Which molecule is the 'key to coagulation'?


 :-- Thrombin




Identify the 3 main functions of thrombin.


 :-- 1. Converts fibrinogen to fibrin + fibrin split products

2. Activates Factors V and VIII

3. Activates platelets



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, 4
Elscores: Aug. 27, 24- 2024/2025



Which molecule is the 'key to anticoagulation'?


 :-- Antithrombin III




Identify the 2 main functions of antithrombin III.


 :-- 1. Binds and inhibits thrombin

2. Inhibits Factors IX, X, and XI




What is the effect of heparin on antithrombin III?


 :-- Heparin activites AT-III (up to 1000x normal activity)




Identify the 2 main functions of Protein C.


 :-- 1. Degrades Factors V and VIII

2. Degrades fibrinogen




What is the relationship of Protein S to Protein C?


 :-- Protein S is a cofactor for Protein C




What is the relationship of Proteins C & S to Vitamin K?


 :-- Both Protein C and S are vitamin K-dependent




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