©THEBRIGHTSTARS 2024
Pmcol 344 Drug List Exam Study Guide.
Omeprazole - answer✔Inhibits acid secretion in the stomach via the proton pump
Cimetidine - answer✔Inhibits histamine and gastrin stimulated acid secretion via the H2
receptor.
Antacids - answer✔Inorganic weak base salts that neutralize acid in the stomach.
Alginates - answer✔Negative polysaccarides from algae that absorb water and coat stomach
Bisthmuth chelate - answer✔Kills pathogens and bacteria and prevents adherences to wall.
Sucralflate - answer✔Complex of Al(OH)3 dissociates and OH forms gel by attaching to
glycoproteins
Misoprostol - answer✔Stable PGEI2 analogue that increases mucus (EP4), increase
bicarbonate (EP1&2), Inhibit histamine production (EP2&3)
Hyoscine - answer✔Blocks the muscarinic receptor antagonist acting at the vomiting centre and
vestibular nuclei
Metoclopramide - answer✔Inhibits vomiting signaling and promotes GI motility, crosses the
BBB causing dyskinesia
Domperidone - answer✔Inhibits vomiting signaling and promotes GI motility, doesn't cross the
BBB
Ondansetron - answer✔Blocks the 5HT3 receptor stopping the vomiting signal by acting on the
CTZ and visceral afferents
Nabilone - answer✔Anti-emetic cannabinoid
Dexamethasone - answer✔Glucocorticoid that inhibits all stages of inflammation
Aprepritant - answer✔NK1 receptor antagonist
Oral Rehydration - answer✔Restore fluid and electrolyte balances. Addition of glucose aids in
Na/water absorption
, ©THEBRIGHTSTARS 2024
Spasmolytics - answer✔Cause relaxation of the gut to increase time for reabsorption and transit
time
Atropine - answer✔Blocks Ach from contracting the muscle leading to relaxtion. Very
predictable symptoms
Morpine/Codine/Diphenoxalate - answer✔Opiates stop the release of Ach from nerve leading
to less contraction
Loperamide - answer✔Synthetic opioid agonist. Effects GI muscle and ENS to reduce
contraction
Methylcellulose - answer✔Polysaccharide polymer not broken down by gut. Binds water in the
gut reducing fluid volume. Forms hydrated bulky mass. Promotes peristaltic reflux
Lactulose - answer✔Disaccharide of fructose and glucose. Osmotically active molecules that
draws water into lumen.
Senna - answer✔Increase electrolytes and water secretion. Increases peristalsis. Directly
stimulates nerves in the myenteric plexus
Cholinomimetics/Cholinesterase inhibitors - answer✔Enhance GI contractions but they are
uncoordinated so they produce little peristaltic activity
Cisapride - answer✔5HT4 agonist. Targets presynaptic neurons that stimulate the myenteric
plexus. Causes Long QT syndrome due to blockage of HERG channels.
Tegaserod - answer✔5HT4 agonist. Targets presynaptic neurons that stimulate the myenteric
plexus
Pruclopride - answer✔Newest 5HT4 agonist. Targets presynaptic neurons that stimulate the
myenteric plexus
Lubiprostone - answer✔PGE1 analog. Increases cAMP via EP4 receptors to promote Cl
channels (CFTR) and promote fluid secretion
Sulfazalazine - answer✔Prodrug that is converted to 5-ASA. Scavenges free radicals and
inhibitis prostaglandin
Infliximab - answer✔Chimeric antibody that stop TNF-alpha from causing inflammation
Adalimumab - answer✔Humanized antibodies that stop TNF-alpha from causing inflammation.
Also suppresses formation of IL6/1. Causes cellular depletion via CD or ADCC
Galimumab - answer✔Humanized antibodies that stop TNF-alpha from causing inflammation
Vedolizumab - answer✔Anti-alpha 4 beta 7 intern. Prevents T cell activation
Pmcol 344 Drug List Exam Study Guide.
Omeprazole - answer✔Inhibits acid secretion in the stomach via the proton pump
Cimetidine - answer✔Inhibits histamine and gastrin stimulated acid secretion via the H2
receptor.
Antacids - answer✔Inorganic weak base salts that neutralize acid in the stomach.
Alginates - answer✔Negative polysaccarides from algae that absorb water and coat stomach
Bisthmuth chelate - answer✔Kills pathogens and bacteria and prevents adherences to wall.
Sucralflate - answer✔Complex of Al(OH)3 dissociates and OH forms gel by attaching to
glycoproteins
Misoprostol - answer✔Stable PGEI2 analogue that increases mucus (EP4), increase
bicarbonate (EP1&2), Inhibit histamine production (EP2&3)
Hyoscine - answer✔Blocks the muscarinic receptor antagonist acting at the vomiting centre and
vestibular nuclei
Metoclopramide - answer✔Inhibits vomiting signaling and promotes GI motility, crosses the
BBB causing dyskinesia
Domperidone - answer✔Inhibits vomiting signaling and promotes GI motility, doesn't cross the
BBB
Ondansetron - answer✔Blocks the 5HT3 receptor stopping the vomiting signal by acting on the
CTZ and visceral afferents
Nabilone - answer✔Anti-emetic cannabinoid
Dexamethasone - answer✔Glucocorticoid that inhibits all stages of inflammation
Aprepritant - answer✔NK1 receptor antagonist
Oral Rehydration - answer✔Restore fluid and electrolyte balances. Addition of glucose aids in
Na/water absorption
, ©THEBRIGHTSTARS 2024
Spasmolytics - answer✔Cause relaxation of the gut to increase time for reabsorption and transit
time
Atropine - answer✔Blocks Ach from contracting the muscle leading to relaxtion. Very
predictable symptoms
Morpine/Codine/Diphenoxalate - answer✔Opiates stop the release of Ach from nerve leading
to less contraction
Loperamide - answer✔Synthetic opioid agonist. Effects GI muscle and ENS to reduce
contraction
Methylcellulose - answer✔Polysaccharide polymer not broken down by gut. Binds water in the
gut reducing fluid volume. Forms hydrated bulky mass. Promotes peristaltic reflux
Lactulose - answer✔Disaccharide of fructose and glucose. Osmotically active molecules that
draws water into lumen.
Senna - answer✔Increase electrolytes and water secretion. Increases peristalsis. Directly
stimulates nerves in the myenteric plexus
Cholinomimetics/Cholinesterase inhibitors - answer✔Enhance GI contractions but they are
uncoordinated so they produce little peristaltic activity
Cisapride - answer✔5HT4 agonist. Targets presynaptic neurons that stimulate the myenteric
plexus. Causes Long QT syndrome due to blockage of HERG channels.
Tegaserod - answer✔5HT4 agonist. Targets presynaptic neurons that stimulate the myenteric
plexus
Pruclopride - answer✔Newest 5HT4 agonist. Targets presynaptic neurons that stimulate the
myenteric plexus
Lubiprostone - answer✔PGE1 analog. Increases cAMP via EP4 receptors to promote Cl
channels (CFTR) and promote fluid secretion
Sulfazalazine - answer✔Prodrug that is converted to 5-ASA. Scavenges free radicals and
inhibitis prostaglandin
Infliximab - answer✔Chimeric antibody that stop TNF-alpha from causing inflammation
Adalimumab - answer✔Humanized antibodies that stop TNF-alpha from causing inflammation.
Also suppresses formation of IL6/1. Causes cellular depletion via CD or ADCC
Galimumab - answer✔Humanized antibodies that stop TNF-alpha from causing inflammation
Vedolizumab - answer✔Anti-alpha 4 beta 7 intern. Prevents T cell activation
