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NPLEX II Pharmacology Questions and Correct Answers | Latest Update
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5-fluorouracil -:- SE: Inflammation of mouth, loss of appetite, low blood cells, inflammation of skin, hair loss. Use: Cancer, Actinic Keratosis, BCC Interactions/CI: Don't use in pregnancy, bone marrow suppression. Mechanism: Antimetabolite, pyrimidine analog. Delivery: Injectable for can...

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  • September 19, 2024
  • 182
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • nplex ii pharmacology questions and correct answer
  • 5 fluorouracil se inflammation of mouth lo

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2024 /2025 | © copyright | This work may not be copied for profit gain Excel!




NPLEX II Pharmacology Questions and
Correct Answers | Latest Update
5-fluorouracil


✓ -:- SE: Inflammation of mouth, loss of appetite, low blood cells,

inflammation of skin, hair loss.




Use: Cancer, Actinic Keratosis, BCC




Interactions/CI: Don't use in pregnancy, bone marrow suppression.




Mechanism: Antimetabolite, pyrimidine analog.


Delivery: Injectable for cancer, cream for actinic keratosis, BCC.




Amantadine


✓ -:- SE: CNS such as anxiety and difficulty swallowing. , seizures.




Use: Anti viral, but mostly anti-parkinson




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,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!



Interactions: Used in tandem with L-Dopa for parkinsons, Interacts with HCT, anti

depressents.




Mechanism: Antagonist of NMDA glutamate receptor, increases dopamine and blocks

reuptake.




Delivery:




Amiodarone


✓ -:- SE: Liver issues, arrhythmias, vision, thyroid and teeth issues. Wolff

Chaikoff due to iodine content.




Use: Antiarrhythmic for VT, VF, and AF.


Interactions: Danger with digitalis. . Potentiates Warfarin, CP450. No use with cyclosporine,

flecainide, procainamide etc.




Contraindicated: with Sinus nodal bradycardia, atrioventricular block and secondary or

tertiary block without a pacemaker.




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,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!



Mechanism: Increases time before heart cells can contract. Phase 3 prolongs refractory

period at SA and AV node.




Acyclovir


✓ -:- SE: Nausea, diarrhoea, safe in pregnancy, low platelets.




Use: Antivirals for HSV, shingles, cytomegalovirus, epstien Barr.




Interactions: synergy with ketoconazole. Probenecid extends. Same with interferon and

zidovudine.




C/I:




Mechanism: analog of guanisine, decreases viral DNA.




Adalimumab


✓ -:- SE: Increases risk of infections, blood disorders, lymphoma, cancer,

liver injury.


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, 2024 /2025 | © copyright | This work may not be copied for profit gain Excel!




Use: Used in RA, psoriasis, ankylosing spondylitis, crohn's UC.




Interactions: doubles effect of methotrexate.




CI: Infections




Mechanism: TNF inhibiting anti-inflammatory biologic.




Adefovir


✓ -:- SE: Kidney toxicity in high dosages. Lactic acidosis




Use: Chronic Hep B. HSV




Interactions:




CI: Kidney disease



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