Endothelial dysfunction (endothelial dysfunction syndrome) Qs&As A+

Endothelial dysfunction (endothelial dysfunction syndrome) Qs&As A+ endothelium and its function - ANS-regulation of vascular tone blood clotting inflammation basement membrane permeability regulation of cell growth endothelium and its function (regulation of vascular tone) - ANS-makes NO and cytokines for vasoconstriction/vasodilation endothelium and its function (blood clotting) - ANS-Blood clot prevention - NO, PGI2(aka prostacyclin), and thrombomodulin (thrombomodulin binds thrombin - activation of protein C - anticoagulation) endothelium and its function (inflammation) - ANS-Regulates inflammation- makes substances that promote or inhibit inflammation Also regulates immunity endothelium and its function (basement membrane permeability) - ANS-Vascular permeability and therefore cell metabolism Things that can cause endothelial damage (and endothelial dysfunction) include: - ANS-- Lifestyle habits - metabolic syndrome - LDL - T1 and T2D - hyperglycemia(both) and hyperinsulinemia in T2D cause macroangiopathy - EDS - Smokin... Continues...