NU 327 Musculoskeletal Exam
Questions and Answers All Correct
(Newest Version)
What is the treatment of osteoarthritis? - Answer- - relieve pain (NSAIDS may cause GI
bleeding)
- maintain mobility
- minimize disability
- exercise
- lifestyle
- medications
What is the etiology of rheumatoid arthritis? - Answer- - *systemic/chronic autoimmune
inflammatory response
- idiopathic
- most likely an abnormal autoimmune response
What is the patho. of rheumatoid arthritis? - Answer- - body attack synovial tissues
- inflammatory response
- destruction
- persistent destructive autoimmune process
What are the S&S of rheumatoid arthritis? - Answer- - *symmetrical*, tender, swollen
joints
- fatigue
- painful, stiff joints lasting 30 min to 1 hr in the morning
- subcutaneous rheumatoid nodules
- permanent damage to surfaces of joints (swan-neck, boutonniere, Baker's cysts,
nodules in lungs)
- limited mobility
- elevated RF, ESR, CRP
What is the treatment of rheumatoid arthritis? - Answer- - alleviate pain and swelling
- anti-inflammatory agents
- DMARDS
- immunosuppressive drugs
- biological agents
- anti-TNF alpha biological agents
- antimalarial drugs
, What is the etiology of Systemic Lupus Erythematosus (SLE)? - Answer- - chronic,
multisystem inflammatory autoimmune dz affecting connective tissue
- environmental (sunlight may initiate development)
- abnormal immune rxn of the body against its own tissues, cells, and serum proteins
- no cure
What is the patho. of SLE? - Answer- - formation of autoantibodies
- *antibodies deposited in organs and tissues*
- antibodies trigger inflammatory response
- destruction of microvasculature
What are the S&S of SLE? - Answer- - *joint inflammation*
- *neurologic*
- *cardiopulmonary*
- *vascular - hematologic*
- *skin lesions*
- fever, fatigue, morning stiffness, sunlight worsens
How do you diagnose SLE? - Answer- - presence of 4: rash, mouth sores, arthritis,
lung/heart inflammation, kidney problem, neurological problem, abnormal labs
- labs: anemia, low WBCs, low platelets, antibodies
How do you treat SLE? - Answer- - NSAIDS, antimalarial drugs, corticosteroids,
methotrexate, immunosuppressive
- GOAL: reduce amount of time of exacerbation
What is the etiology of scleroderma? - Answer- - chronic, multisystem, autoimmune
inflammatory connective tissue disease
- abnormal fibrous tissue accumulation
- can affect skin, blood vessels, synovium, skeletal muscle, and microvasculature of
internal organs
What is the patho. of scleroderm? - Answer- - inflammation and immune cell infiltration
can be found in skin, lungs, and tissues
- tissue ischemia and fibrosis
- cytokines cause increased collagen and other connective tissue components
What are the S&S of scleroderma? - Answer- - muscle aches, joint pain, swelling
- Raynaud's
- sclerodactyly
- contractures
- polyathritis
- gastrointestinal
- atrophy of muscles
- pulmonary fibrosis
- CHF, renal, CREST: Calcinosis, Raynaud, Esophageal, Telangiectasia
