develop schizophrenia correct answers -Many genes play a role
• as do epigenetic factors
• Heritability as high as 79%
-gene-environment interaction
-Environmental Triggers:
• Regular Cannabis Use
• Exposure to Early Life Trauma
Sexual Abuse
Emotional Abuse
Emotional Neglect
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develop schizophrenia correct answers -Many genes play a role
• as do epigenetic factors
• Heritability as high as 79%
-gene-environment interaction
-Environmental Triggers:
• Regular Cannabis Use
• Exposure to Early Life Trauma
➣Sexual Abuse
➣Emotional Abuse
➣Emotional Neglect
➣Bullying
-Orbitofrontal & connections to the amygdala: aggressive, impulsive symptoms
Brain Circuits Affected in Schizophrenia: correct answers -Dopamine Pathways
• explain the (+) & (-) symptoms seen in schizophrenia & psychosis
Dopamine Role in Psychosis correct answers -leading hypothesis
• psychosis & schizophrenia associated with dysfunction of neurotransmitter dopamine (DA)
➣Traditionally surplus of dopamine
Glutamate Role in Psychosis correct answers -primary excitatory neurotransmitter
-implicated in the overactivity of mesolimbic DA pathway in schizophrenia
-Glutamate hypoactivity may result in lost activation of the mesocortical dopamine pathway
leading to negative symptoms of schizophrenia
GABA is the primary _________ neurotransmitter correct answers inhibitory
• Persecution: delusions related to being threatened, victimized, or spied on
• Reference: delusions related to receiving personal messages from television (tv), radio, or
actions of others
• Somatic: delusions related to the body, including illness or the presence of foreign objects (e.g.
Sometimes people believe there are objects in their bodies; for example they might think they are
infested with insects.)
• Grandeur: delusions related to beliefs of special abilities or powers
• Control: delusions that actions and thoughts are controlled by others
Thought Disorder: correct answers -impairment in the process of thinking & difficulty
organizing thoughts in a logical pattern
• incoherent speech
• loose associations
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