NRSG 3100 Exam #6
Most common coagulation disorder - correct answer ✔thrombocytopenia
THERAPUTIC aPTT - correct answer ✔60-80
MOA of anticoagulants - correct answer ✔Lengthen clotting time and prevent
thrombi from forming or growing larger
They do NOT dissolve clots: prevent growing
Onset for IV heprian - correct answer ✔Immediate
Onset for SQ heprian - correct answer ✔About an hour
AE heprian - correct answer ✔Abnormal bleeding,
possible allergies (animal products), osteoporosis!!!!
caution with renal or hepatic failure
HIT!!!!
HIT - correct answer ✔Heparin-induced thrombocytopenia occurs in up to
5% of patients; markedly INCREASES platelet aggregation and thrombolytic
events
CI for heprian - correct answer ✔Internal bleeding,
intracranial hemorrhage,
severe HTN,
bacterial endocarditis!!!!
, , severe thrombocytopenia
BBW for heprian - correct answer ✔Epidural or spinal hematomas may occur
in clients with epidural or lumbar puncture
Onset of protamine sulfate - correct answer ✔5 minutes
DI for heprian - correct answer ✔nicotine,
digoxin,
tetracycline,
antihistamines.
Ginger,
garlic,
green tea,
and gingko.
Pregnancy and heprian - correct answer ✔Does not cross placental barrier
and is not secreted in breast milk; anticoagulant of choice for pregnancy and
lactation. Caution during the peripartum period.
Difference between lovenox and heprian - correct answer ✔Unable to bind
thrombin; More selective for Factor Xa inhibition
Advantages of Enoxaparin (Lovenox) - correct answer ✔More predictable
response; dose determined based on weight!!!
Less frequent monitoring
Half-life is 2-4 times longer than heparin
Once daily dosing, SQ
Most common coagulation disorder - correct answer ✔thrombocytopenia
THERAPUTIC aPTT - correct answer ✔60-80
MOA of anticoagulants - correct answer ✔Lengthen clotting time and prevent
thrombi from forming or growing larger
They do NOT dissolve clots: prevent growing
Onset for IV heprian - correct answer ✔Immediate
Onset for SQ heprian - correct answer ✔About an hour
AE heprian - correct answer ✔Abnormal bleeding,
possible allergies (animal products), osteoporosis!!!!
caution with renal or hepatic failure
HIT!!!!
HIT - correct answer ✔Heparin-induced thrombocytopenia occurs in up to
5% of patients; markedly INCREASES platelet aggregation and thrombolytic
events
CI for heprian - correct answer ✔Internal bleeding,
intracranial hemorrhage,
severe HTN,
bacterial endocarditis!!!!
, , severe thrombocytopenia
BBW for heprian - correct answer ✔Epidural or spinal hematomas may occur
in clients with epidural or lumbar puncture
Onset of protamine sulfate - correct answer ✔5 minutes
DI for heprian - correct answer ✔nicotine,
digoxin,
tetracycline,
antihistamines.
Ginger,
garlic,
green tea,
and gingko.
Pregnancy and heprian - correct answer ✔Does not cross placental barrier
and is not secreted in breast milk; anticoagulant of choice for pregnancy and
lactation. Caution during the peripartum period.
Difference between lovenox and heprian - correct answer ✔Unable to bind
thrombin; More selective for Factor Xa inhibition
Advantages of Enoxaparin (Lovenox) - correct answer ✔More predictable
response; dose determined based on weight!!!
Less frequent monitoring
Half-life is 2-4 times longer than heparin
Once daily dosing, SQ
