,Pharmacologic Principles Correct Answer-Pharmaceutics
Pharmacokinetics
Pharmacodynamics
Pharmacotherapeutics
Toxicity
(NOT ALL OF THEM, JUST THE ONES WE NEED TO KNOW)
Pharmaceutics Correct Answer-The study of how various drug forms
influence the way in which the drug affects the body
Dissolution/dissolving of solid dosage forms and their absorption
Pharmacokinetics Correct Answer-Absorption
Distribution
Metabolism
Excretion
Absorption Correct Answer-Moving the drug through the body
From the site of administration into the blood stream for distribution to
the tissues
NEED TO KEEP IN MIND:
The rate of absorption (how quickly the drug will take effect)
,The amount of absorption determines the intensity of the effect
Bioavailability (Absorption) IMPORTANT Correct Answer-A measure
of the extent of drug absorption for a given drug and route
Properties of the drug
Route of administration of the drug
First Pass Effect (Absorption) Correct Answer-A phenomenon that
occurs during drug metabolism.
Drugs taken orally begin to metabolize in the liver and the concentration
of the drug is decreased by less than 100% before it reaches the blood
stream. (DRUG IS CHEMICALLY CHANGED DUE TO
METABOLITES IN THE LIVER)
IV drug metabolism has a direct effect and concentration due to the
direct administration to the blood.
*Think* ORAL = FILTERED, IV = DIRECT DOSAGE
Drugs with little to no first pass effect Correct Answer-
BIOAVAILABILITY IS INCREASED
, IV drugs, IM drugs, and under the tongue drugs
Enteral Route (Absorption) Correct Answer-Drug absorbed into the
systemic circulation through the mucosa of the stomach and intestines
Oral, Sublingual, buccal, rectal
Enteric coated = protects the GI tract and stomach (DO NOT CRUSH
OR BREAK)
Anticholinergic drugs slow the GI tract transit time (reduces the amount
of absorption in the stomach and allows more drug to pass)
Parenteral Route (Absorption) Correct Answer-Any route of
administration other than the GI tract
FASTEST Route
ID, IM, IV, SubQ, IA (arterial), Intrathecal (epidural)
Injections, solutions, suspensions, emulsions, powders, etc.
Topical Route (Absorption) Correct Answer-Application of medications
to the various outside surfaces of the body
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