GMS 6504 Review Exam 2 Questions And Answers With Complete Updates
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Course
GMS 6504
Institution
GMS 6504
GMS 6504 Review Exam 2 Questions And Answers With Complete Updates
In terms of Lipinski's rules, which of the following functional groups serves as a hydrogen bond donor?
A. -Cl
B. -NO2
C. =O
D. -SO3
E. -NH2
E. -NH2
Will a hydrophobic molecule have a high or low logP?
A. High
B. Low
A. H...
GMS 6504 Review Exam 2 Questions And Answers
With Complete Updates
In terms of Lipinski's rules, which of the following functional groups serves as a hydrogen bond
donor?
A. -Cl
B. -NO2
C. =O
D. -SO3
E. -NH2
E. -NH2
Will a hydrophobic molecule have a high or low logP?
A. High
B. Low
A. High
Which is the best explanation as to why CNS drugs tend to have smaller polar surface areas than
drugs that target things outside of the CNS?
A. The receptors in the CNS tend to be small proteins
B. It helps the drug cross the blood brain barrier
C. Larger drugs will be metabolized faster
D. It will cause them to be sequestered in the brain
E. Absorption is particularly important for CNS drugs
B. It helps the drug cross the blood brain barrier
Which functional group is most often utilized when making pro-drugs?
A. Amides
B. Carbonates
C. Ethers
D. Phosphates
E. Esters
E. Esters
Which of the following protein domains would you expect to find in an “easily druggable” target but
NOT in an “undruggable” target?
A. Extracellular domain
B. Instracellular domain
C. Membrane spanning domain
, D. ATP-binding domain
E. Protein binding domain
D. ATP-binding domain
Would using a drug against cells in which it causes synthetic lethality tend to increase or decrease its
therapeutic index?
A. Increase
B. Decrease
A. Increase
Inhibition of which enzyme is expected to cause synthetic lethality in cells harboring a BRCA2
mutation?
A. Rb
B. EGFR
C. PARP
D. MYCN
E. CDK2
C. PARP
Kinases place which functional group on proteins?
A. Amides
B. Carbonates
C. Ethers
D. Phosphates
E. Esters
D. Phosphates
Which of the following could be the sequence of the catalytic site of a kinase?
A. APYGNQ
B. GKSRPW
C. MMQSAR
D. YKLVCC
E. GIGSAG
E. GIGSAG
What amino acid most commonly serves as the gatekeeper residue in a kinase?
A. Threonine
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