NURS 615 (NURS615)

Charlie is a 65-year-old male who has been diagnosed with hypertension and benign prostatic hyperplasia. Doxazosin has been chosen to treat his hypertension because it: a. Increases peripheral vasoconstriction b. Decreases detrusor muscle contractility c. Lowers supine blood pressure more than standing pressure d. Relaxes smooth muscle in the bladder neck Answer d. Relaxes smooth muscle in the bladder neck To reduce potential adverse effects, patients taking a peripherally acting alpha1 ...

What is tiotropium? Answer (Spiriva) Tiotropium bromide (INN) is a long-standing, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease, (COPD). What is tiotropium used for maintenance treatment of? Answer COPD, which includes chronic bronchitis and emphysema. Tiotropium Answer is not used in the treatment for acute exacerbations of COPD and bronchitis Tiotropium Answer is a muscarinic receptor antagonist, often referred to as an antimus...

early part of drug development Answer preclinical stage phase one clinical trials Answer establish biological effects as well as safe dosages and pharmacokinetics in a small number of healthy patients phase two clinical trials Answer new drug used to treat disease in a small number of patients and establish the potential of the drug to improve outcomes phase three clinical trials Answer compare the new medication to standard therapy two types of drug responses Answer quantal and grad...

Oseltamivir (Tamiflu) Answer Neuramidase Inhibitor. Oral Antiviral for influenza A&B. Works by breaking the bond that attaches the viral particles to host cell. SE include headache, n/v, and CNS. Zanamivir (Relenza) Answer Neuramidase Inhibitor. Inhaled Antiviral for influenza A&B. Works by breaking the bond that attaches the viral particles to host cell. Contraindicated for COPD. SE include headache, n/v, and CNS. Amantadine (Symmetrel) Answer Inhaled Antiviral for Influenza A. Works by b...

1. Henry has recently started on carbamazepine to treat seizures. He comes to see you and you note that while his carbamazepine levels had been in the therapeutic range they are now low. The possible cause for the low carbamazepine levels include: Answer Carbamazepine auto-induces metabolism, leading to lower levels despite good compliance. 2. Carbamazepine has a Black Box Warning due to life-threatening: Answer Dermatologic reaction, including Steven's Johnson and toxic epidermal necrolysis...

What is Tiotropium (SPIRIVA) used to treat? Answer Used in the management/ maintenance treatment of chronic obstructive pulmonary disease (COPD) which includes chronic bronchitis and emphysema. What is the drug classification of Tiotropium? Answer >It is a long-acting, 24H anticholinergic-bronchodilator. >It is a muscurinic receptor antagonist, often referred to as an antimuscurinic or anticholinergic agent. What is the mechanism of action of Tiotropium (SPIRIVA) Answer It does not ...

What are the precautions and contraindications when prescribing phentermine? Answer It carries a high risk of tolerance and dependence, physically and psychologically. Caution using with patients with history of alcohol or drug dependence because of cross-tolerance. Actively drinking alcoholics can get depression, paranoia, or psychoses when taking phentermine. Use should be limited to max of 6 months. Contraindicated in patients who abuse substances such as cocaine, meth or PCP because of poten...

Low-dose colchine Answer 1.2 mg at first sign of flare, followed by 0.6 mg one hour later for a total dose of 1.8 mg. High-dose colchine Answer 1.2 mg followed by 0.6 mg every 4-6 hours totaling 4.8 mg. Gout Answer BUN, creatinine, and creatinine clearance should be monitored in the treatment of this disease Colchine Answer This medication can cause severe diarrhea, nausea, vomiting, abdominal pain Febuxostat (Uloric) Answer When prescribing this medication, patients should be taught...

How does carbamazepine work? Answer Works by decreasing nerve impulses that cause seizures and pain How often should carbamazepine lab values be monitored? What labs? Answer CBC q 3-4 months What anti-seizure med auto induces metabolism? Answer Carbamazepine What medication decreases the production of RBCs, WBCs, and platelets? Answer Carbamazepine What is carbamazepine half-life? Answer Single dose: 30 hours Multiple dose: 15 hours What is a great risk of seizure potential while...

Carbamazepine (Tegretol) can sometimes show subtherapeutic range due to what? Answer Carbamazepine auto-induces metabolism, leading to lower levels despite good compliance What are the black box warnings for Carbamazepine? Answer Dermatologic reactions 1. Steven's Johnson 2. Toxic epidermal necrolysis What lab test should be ordered for patients on Carbamazepine? Answer CBC every 3-4 months because it can cause decreased WBC, decreased platelets, and trouble with RBC What kind of tea...