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Pharmacokinetics I – Flashcards Questions With Correct Answers Intestine Location of drug distribution Liver Location of drug distribution Kidney Location of drug distribution Blood-brain barrier Location of drug distribution Cancer cells Location of drug distribution Tablet (Oral) Drug administration route

Pharmacokinetics I - Practice Test Questions With Answers What are the characteristics of SoLute Carrier (SLC) transporters? Carriers for small molecules across the membrane, Expressed in many different epithelial membranes, Include over 300 members organized into 52 families Why does intravenous drug administration bypass drug absorption and metabolism? To deliver the drug directly into the bloodstream Why do carrier proteins transport drugs based on their chemical characteristics? T...

Pharmacokinetics I – Flashcards Questions And Answers Critical Thinking Intravenous drug administration bypasses drug absorption and metabolism, Carrier proteins transport drugs based on their chemical characteristics P-glycoprotein (P-gp) Active efflux pump for anticancer drugs, Member of ATP-binding cassette (ABC) transporters Organ distribution P-gp: Intestine, Liver, Kidney, Placenta, Blood-brain barrier (BBB), Pancreas, Colon, Testis, BCRP: Intestine, Liver, Kidney, Placenta, B...

Pharmacokinetics I – Flashcards Questions With Correct Answers Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Plasma protein binding, Tissue binding and absorption/transport Small Intestinal transporters Influx and efflux transporters in both lumen and blood sides Liver transporters More influx than efflux transporters in the blood side, more efflux than influx transporters in the bile side

Pharmacokinetics I - Practice Test Questions And Answers What are the major locations of drug distribution? Intestine, liver, kidney, blood-brain barrier, cancer cells What are the different drug administration routes? Tablet (Oral), Capsule (Oral), Cream and ointment/intradermal injection (Percutaneous absorption), Intravenous/subcutaneous/intramuscular/intradermal injection, Direct injection to the site What is gastrointestinal absorption & transport? Absorption and transport in the...

Pharmacokinetics I – Flashcards Questions With Answers Organ distribution Intestine, Liver, Kidney, Placenta, Blood-brain barrier (BBB), Pancreas, Colon, Testis Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Gut transport, Liver metabolism, Cardiac output and blood flow, Physicochemical properties of drugs, Plasma protein binding, Tissue binding and absorption/transport Small Intestinal transporters Almost equal number of influx and efflux transp...

Pharmacokinetics I - Practice Test Questions With Correct Answers What factors affect drug distribution? Gut transport, Liver metabolism, Cardiac output and blood flow, Physicochemical properties of drugs, Plasma protein binding, Tissue binding and absorption/transport Why are there almost equal numbers of influx and efflux transporters in both lumen and blood sides of the small intestine? To facilitate drug transport Why are there more influx than efflux transporters in the blood sid...

Pharmacokinetics I - Practice Test Questions With Correct Answers Why are there more influx than efflux transporters in the blood side, while more efflux than influx transporters in the bile side of the liver? To facilitate the uptake of nutrients from the blood and the excretion of waste into the bile Why do cancer cells maintain more nutrient concentrations than drugs? To support their rapid growth and proliferation What are the different drug administration routes? Tablet (Oral), C...

Pharmacokinetics I – Flashcards Questions And Answers P-glycoprotein (P-gp) Active efflux pump for anticancer drugs, Member of ATP-binding cassette (ABC) transporters Organ distribution Intestine, Liver, Kidney, Placenta, Blood-brain barrier (BBB), Pancreas, Colon, Testis P-gp Abundance Intestine, Liver, Kidney, Placenta, BBB, Pancreas, Colon, Testis Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Plasma protein binding, Tissue binding and absorp...

Pharmacokinetics I - Practice Test Questions And Answers What is the volume of distribution (Vd)? Amount of drug in the body/plasma drug concentration What factors affect drug distribution? Gut transport, Liver metabolism, Cardiac output and blood flow, Physicochemical properties of drugs, Plasma protein binding, Tissue binding and absorption/transport Why does active/efflux transport require an energy source (ATP)? To transport drugs against their concentration gradient