Sbcp Study guides, Class notes & Summaries

The minor pathway (CYP450 2E1) - Answer Produces toxin --> detoxified by glutathione in liver - but fixed quantity/ 24 hrs Excess toxins damage liver and encourages inflammation --> reversible or irreversible damage Acetylcysteine admin IV <8hrs replaces glutathione Heavy metals include: - Answer · iron, Lead, mercury, gold, arsenic, copper

A drug given by which route would be associated with the greatest first pass effect - Answer Oral Anastasia takes a single dose of 1500mg of paracetamol, if the half life of the drug is two hours, approximately how many hours will it be before her plasma concentration of the drug falls to 375mg? - Answer 4 hours Regarding the paracetamol dose of 1500mg, how many half lives will have passed when the drug falls below the minimum effectiveness concentration (MEC) of 300mg? -

Cellular Adaptation observable in the goblet cells of a smokers respiratory tract ~ Hypertrophy Which of the following types of adaptive cell responses has the greatest potential to progress into neoplasia ~ Dysplasia A sign is ~ An objective measurement or recording Which of the following is an inherited genetic factor that influences cellular ageing ~ DNA repair defects A patient is in severe pain. Which route of administration would produce the most rapid relief ~ Intravenou...

SBCP: Clinical biochemistry EXAM | Questions and Answers Latest {} A+ Graded | 100% Verified

What increases the likelihood of drugs exacerbating symptoms Multiple medial conditions Drug interactions that are harmful are - Answer Wargarin and aspirin for headaches can increase the chance of bleeding What increases the likelihood for comorbidities - Answer Older age If a patient is more sensitive to drugs, have greater individual age and their organs are immature, what is the patients group? Paediatrics

Infants less than 1 year old are more sensitive to drug doses than older children, because infants: - Answer Have a slower rate of drug metabolism Epilepsy medications must be continued while a woman is pregnant, as seizures can be harmful for the baby. Which of the following changes that occur during pregnancy will NOT reduce the plasma concentration of the drug? - Answer Increased absorption

SBCP Exam | Questions and Answers Latest {} A+ Graded | 100% Verified

SBCP Mid Practice Exam | Questions and Answers Latest {} A+ Graded | 100% Verified

Rectal Route - Answer · Useful if person is vomiting or unconscious · 50% of absorbed drug will bypass the liver · Absorption is often irregular and incomplete · E.g. antiemetics Parenteral (outside the Intestines) 1 route are: - Answer Intra-venous Intra-muscular Sub-cutaneous Parenteral 2 routes are - Answer Inhalation Topical What type of drug binds to target issues? - Answer free drugs