Cyp2d6 - Study guides, Class notes & Summaries

Focus on Nursing Pharmacology - Amy M. Karch - Chapter 21 Exam with Complete Solutions 100% Solved What is main metabolism way of antidepressant? - answerHepatic metabolism Substrate of CY2D6? - answerTCA, venlafaxine Inhibitor of CYP2D6? - answerParoxetine Sertraline Fluoxetine Citalopram Duloxetine Inhibitor of CYP3A4 - answerFluoxetine Nefazodone Inhibitor of CYP1A2 - answerFluvoxamine What is CYP2D6 polymorphism? - answerDifferent patient will have from normal to different gene...

Risks of vaccines [minor SE: local tender, red, swelling at the injection site, low grade fever, behavioral changes within hours-day of administration] Vaccines are: Safe, effective, serious disease can occur in unvaccinated individuals for routine immunizations are among the safest and most reliable drugs available (most studied in kids) Factors that contribute to hesitancy Lack of information on vaccines Lack of information on diseases that vaccines prevent and their severity Informat...

A patient has endured several dosage adjustments of his tricyclic antidepressant, so the provider recommends genetic testing. Which statement correctly describes the rationale for genetic testing? a. The CYP2D6 gene influences metabolism of tricyclic antidepressants and certain other drugs. b. The HER2 gene is a tumor marker that impacts metabolism of tricyclic antidepressants. c. The BRCA2 gene influences metabolism of certain drugs and increases the risk for breast cancer. d. The x linke...

Which CYP-interacting drugs increase the levels of propranolol and metoprolol? correct answer: CYP2D6 inhibitors (e.g. amiodarone, paroxetine) How does digoxin benefit CHF? Atrial fibrillation? correct answer: Digoxin is a mild positive ionotrope to help HF and is a negative chronotrope to help Afib. Which beta-blocker is more likely to cause CNS side effects, such as depression and insomnia? Why correct answer: Propranolol will have more CNS side effects due to its greater lipid solubi...

Warfarin (Coumadin) - ️️CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin epoxide reductase complex, subunit 1 (VKORC1) Chronic Myelogenous Leukemia (CML) - ️️t(9;22) aka Philadelphia Chromosome, translocation occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of the Abelson Leukemia virus tyrosine kinase (c-abl) o...

NR 565 PHARM MIDTERM EXAM REVIEW QUESTIONS AND ANSWERS, GRADED A+/ VERIFIED/ CYP2D6 - -Need to increase doses of SSRI, beta blockers etc. Codeine can be deadly CYP2C9 - -Decrease warfarin dose Test for gene VCORC1 mutation CYP3A4 - -Decreases elimination Increase toxicity of Amio Schedule I - -no accepted medical use in the US it may not be prescribed. heroin,various opium derivatives,hallucinogenic substances Schedule II - -No refills, no telephone orders Narcotics, Stimulants, Depr...

Focus on Nursing Pharmacology - Amy M. Karch - Chapter 21 Exam with Complete Solutions 100% Solved What is main metabolism way of antidepressant? - answerHepatic metabolism Substrate of CY2D6? - answerTCA, venlafaxine Inhibitor of CYP2D6? - answerParoxetine Sertraline Fluoxetine Citalopram Duloxetine Inhibitor of CYP3A4 - answerFluoxetine Nefazodone Inhibitor of CYP1A2 - answerFluvoxamine What is CYP2D6 polymorphism? - answerDifferent patient will have from normal to different gene...

PRE-NAPLEX EXAM Questions with 100% Correct Answers what is a nutrient for preventing congenital neural tube defects folic acid is a helpful vitamin for pregnant women because it helps prevent birth defects of a baby's brain. Folic acid helps form the neural tube (?)what are the 3 factors that increase rate of dissolution 1. inc temp 2. reducing viscosity of the medium 3. increasing agitation intensity of the medium temperature, amount of stirring,surface area (solute) what p...

NU636 Quiz 1 1. A type B adverse drug reaction (ADR) is one that is unrelated to the pharmacologic action of the drug. They are precipitated by secondary pharmacologic actions of the drug, may be unpredictable, and may or may not be dose dependent. ADRs observed by practitioners should be reported to the FDA through which program? A. Vaccine Injury Program B. NIH Clinical Trial Monitoring Program C. MedWatch Program D. Patient Injury Program 2. Your patient has undergone genetic testing a...

G-Protien coupled receptors and how they interact with drugs - G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane and trap the molecule into the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then enter this space and interact with the GRCP. A specific interaction and binding with a site on one or more of the regions of proteins within the GPCR, and drugs bound with the GRCP can stimulate t...