Lipinskis rules - Study guides, Class notes & Summaries

Medicinal Chemistry Exam Review Solution Lipinski's Rules - ANS-An orally active drug should have the following: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular weight under 500 Da An octanol-water partition coefficient less than 5 First Pass Effect - ANS-When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must either increase ...

GMS6504 Exam 2 Questions And Accurate Answers...

Medicinal Chemistry, Exam Elaboration 2024. Lipinski's Rules - Indicate: An orally active drug should have the following: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular weight under 500 Da An octanol-water partition coefficient less than 5 First Pass Effect - Indicate: When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must e...