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IMMUNOLOGY : VACCINATION/IMMUNIZATION GUARANTEED PASS QUALITY NOTES
Immunization is the means of providing specific protection 
against most common and damaging pathogens. 
• The mechanism of immunity depends on the location of the 
pathogen and the mechanism of its pathogenesis. 
• If the mechanism of pathogenesis involves exotoxins, the 
only immune mechanism effective against it would be 
neutralizing antibodies that would prevent its binding to 
the appropriate receptor, while promoting its clearance 
and degradation by phagocytes. 
• Alternatively, if...
- Package deal
- Summary
- • 38 pages •
Immunization is the means of providing specific protection 
against most common and damaging pathogens. 
• The mechanism of immunity depends on the location of the 
pathogen and the mechanism of its pathogenesis. 
• If the mechanism of pathogenesis involves exotoxins, the 
only immune mechanism effective against it would be 
neutralizing antibodies that would prevent its binding to 
the appropriate receptor, while promoting its clearance 
and degradation by phagocytes. 
• Alternatively, if...
PHYSIOLOGY :Thyroid Hormones
Thyroid Hormones 
6-Nov-21 Thyroid Hormones 1 
INTRODUCTION: 
The thyroid gland is an endocrine gland in the 
neck consisting of two lobes connected by an isthmus. 
It is a large ductless gland in the neck that 
secretes hormones regulating growth and development 
through the rate of metabolism. 
The thyroid gland is found at the front of the 
neck below the Adam`s apple. 
Thyroid gland anatomy: 
• The Thyroid Gland is located in the anterior neck, 
spanning between the C5 and T1 vertebr...
- Package deal
- Summary
- • 92 pages •
Thyroid Hormones 
6-Nov-21 Thyroid Hormones 1 
INTRODUCTION: 
The thyroid gland is an endocrine gland in the 
neck consisting of two lobes connected by an isthmus. 
It is a large ductless gland in the neck that 
secretes hormones regulating growth and development 
through the rate of metabolism. 
The thyroid gland is found at the front of the 
neck below the Adam`s apple. 
Thyroid gland anatomy: 
• The Thyroid Gland is located in the anterior neck, 
spanning between the C5 and T1 vertebr...
PHYSIOLOGY : Hypothalamic Hormones
Hypothalamic Hormones 
 
Overview 
• General Anatomy 
• Hormones produced 
• Actions of hormones 
• Regulation of hormone secretion 
• Abnormalities of secretion 
General Anatomy 
• The hypothalamus is named so because it lies under 
the thalamus(‘hypo’ means ‘under’) 
• It is found in the diencephalon. 
• It is located inferior to the thalamus, posterior to the 
optic chiasm and bordered on the sides by the 
temporal lobes and optic tracts. 
• It is almond shaped an...
- Package deal
- Summary
- • 51 pages •
Hypothalamic Hormones 
 
Overview 
• General Anatomy 
• Hormones produced 
• Actions of hormones 
• Regulation of hormone secretion 
• Abnormalities of secretion 
General Anatomy 
• The hypothalamus is named so because it lies under 
the thalamus(‘hypo’ means ‘under’) 
• It is found in the diencephalon. 
• It is located inferior to the thalamus, posterior to the 
optic chiasm and bordered on the sides by the 
temporal lobes and optic tracts. 
• It is almond shaped an...
PHYSIOLOGY : Sensory Physiology Introduction
Sensory Physiology 
Introduction 
• The survival of any organism depends on 
having adequate information about the 
external environment, where food is to be 
found and where hazards abound. 
• Also important for maintaining the function of 
a complex organism is information about the 
state of numerous internal bodily processes 
and functions. 
Introduction 
• Events in the external and internal 
environment must first be translated into 
signals that the nervous systems can proc...
- Package deal
- Summary
- • 63 pages •
Sensory Physiology 
Introduction 
• The survival of any organism depends on 
having adequate information about the 
external environment, where food is to be 
found and where hazards abound. 
• Also important for maintaining the function of 
a complex organism is information about the 
state of numerous internal bodily processes 
and functions. 
Introduction 
• Events in the external and internal 
environment must first be translated into 
signals that the nervous systems can proc...
RECEPTORS OF THE IMMUNE SYSTEM, PHAGOCYTIC CELLS, AND TOLERANCE
RECEPTORS OF THE IMMUNE 
SYSTEM, 
PHAGOCYTIC CELLS, AND 
TOLERANCE 
 Receptors of the innate immune system mediate a number of 
different functions. 
 Many are phagocytic receptors that stimulate ingestion of the 
pathogens they recognize. 
 Some are chemotactic receptors, such as the f-Met-Leu-Phe 
receptor, which binds the N-formylated peptides produced by 
bacteria, and guides neutrophils to sites of infection. 
 A third function is to induce effector molecules, that cont...
- Summary
- • 60 pages •
RECEPTORS OF THE IMMUNE 
SYSTEM, 
PHAGOCYTIC CELLS, AND 
TOLERANCE 
 Receptors of the innate immune system mediate a number of 
different functions. 
 Many are phagocytic receptors that stimulate ingestion of the 
pathogens they recognize. 
 Some are chemotactic receptors, such as the f-Met-Leu-Phe 
receptor, which binds the N-formylated peptides produced by 
bacteria, and guides neutrophils to sites of infection. 
 A third function is to induce effector molecules, that cont...
Principles of Immunology INTRODUCTION
Principles of 
Immunology 
INTRODUCTION 
• The immune system serves as a means to resist infection. 
• It is comprised of two major sub-divisions; The innate and 
adaptive/acquired immune systems. 
• Its main function is to discriminate between self and nonself, thus protecting against invading organisms and to 
eliminate modified or altered cells. 
• There are both cellular and Humoral aspects to both 
adaptive/acquired/specific and innate immune responses. 
• All the cells invo...
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- Summary
- • 101 pages •
Principles of 
Immunology 
INTRODUCTION 
• The immune system serves as a means to resist infection. 
• It is comprised of two major sub-divisions; The innate and 
adaptive/acquired immune systems. 
• Its main function is to discriminate between self and nonself, thus protecting against invading organisms and to 
eliminate modified or altered cells. 
• There are both cellular and Humoral aspects to both 
adaptive/acquired/specific and innate immune responses. 
• All the cells invo...
PHYSIOLOGY OF THE ENDOCRINE SYSTEM : Posterior Pituitary Hormones Antidiuretic hormone Oxytocin
Posterior Pituitary Hormones 
Antidiuretic hormone 
Oxytocin 
November 6, 2021 posterior pituitary 1 
Posterior Pituitary 
• Called neurohypophysis 
– Composed glial cells (pituicytes) 
– They are the supporting cells for 
• Nerve terminals that originate in the supraoptic & 
paraventricular nuclei 
• Nerve endings lie on the capillaries 
– Release vasopressin & oxytocin 
November 6, 2021 posterior pituitary 2 
Hormones of Posterior Pituitary 
• The hormones of the posterior pitu...
- Package deal
- Summary
- • 30 pages •
Posterior Pituitary Hormones 
Antidiuretic hormone 
Oxytocin 
November 6, 2021 posterior pituitary 1 
Posterior Pituitary 
• Called neurohypophysis 
– Composed glial cells (pituicytes) 
– They are the supporting cells for 
• Nerve terminals that originate in the supraoptic & 
paraventricular nuclei 
• Nerve endings lie on the capillaries 
– Release vasopressin & oxytocin 
November 6, 2021 posterior pituitary 2 
Hormones of Posterior Pituitary 
• The hormones of the posterior pitu...
PHYSIOLOGY :PAIN PHYSIOLOGY
Pain 
Pain 
• Many ailments of the body cause pain. 
• The ability to diagnose different diseases 
depends to a great extent on a clinician’s 
knowledge of the different qualities of pain. 
• It occurs whenever tissues are being damaged 
and causes the individual to react to remove the 
pain stimulus. 
• Even simple activities as sitting for a long time on 
the ischium can cause tissue destruction because 
of lack of blood flow to the skin where it is 
compressed by the weight...
- Package deal
- Summary
- • 41 pages •
Pain 
Pain 
• Many ailments of the body cause pain. 
• The ability to diagnose different diseases 
depends to a great extent on a clinician’s 
knowledge of the different qualities of pain. 
• It occurs whenever tissues are being damaged 
and causes the individual to react to remove the 
pain stimulus. 
• Even simple activities as sitting for a long time on 
the ischium can cause tissue destruction because 
of lack of blood flow to the skin where it is 
compressed by the weight...
IMMUNOLOGY ; HUMORAL DEFENCES THE COMPLEMENT SYSTEM ANTIBODIES
HUMORAL DEFENCES 
THE COMPLEMENT SYSTEM 
ANTIBODIES 
• Humoral immunity refers to the non cellular aspects of the immune 
system i.e. antibodies synthesis and the accessory processes that 
accompany it, including: 
• Th2 activation and cytokine production, 
• Germinal centre formation and isotype switching, 
• Affinity maturation and 
• Memory cell generation. 
• It also refers to the effector functions of antibody, which include: 
• Pathogen and toxin neutralization, 
• Classica...
- Package deal
- Summary
- • 78 pages •
HUMORAL DEFENCES 
THE COMPLEMENT SYSTEM 
ANTIBODIES 
• Humoral immunity refers to the non cellular aspects of the immune 
system i.e. antibodies synthesis and the accessory processes that 
accompany it, including: 
• Th2 activation and cytokine production, 
• Germinal centre formation and isotype switching, 
• Affinity maturation and 
• Memory cell generation. 
• It also refers to the effector functions of antibody, which include: 
• Pathogen and toxin neutralization, 
• Classica...
ENDOCRINE SYSTEM; Growth Hormones guaranteed pass
Growth Hormone 
• Growth hormone is also known as 
somatotropin. 
• It is a peptide hormone that stimulates 
growth, cell production and cell regeneration. 
• It is secreted by the anterior lobe of the 
pituitary gland 
September 20, 2022 Growth hormone 3 
Structure 
• Human growth hormone 
– Has 191 AA residues 
– MW 22000 (22K hGH) 
• GH is bound to a protein in plasma 
– ½ Of GH activity is bound which form 
• Reservoir of hormone to 
• Compensate for wide fluctuati...
- Summary
- • 63 pages •
Growth Hormone 
• Growth hormone is also known as 
somatotropin. 
• It is a peptide hormone that stimulates 
growth, cell production and cell regeneration. 
• It is secreted by the anterior lobe of the 
pituitary gland 
September 20, 2022 Growth hormone 3 
Structure 
• Human growth hormone 
– Has 191 AA residues 
– MW 22000 (22K hGH) 
• GH is bound to a protein in plasma 
– ½ Of GH activity is bound which form 
• Reservoir of hormone to 
• Compensate for wide fluctuati...
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