Gpcr - Guides d'étude, Notes de cours & Résumés

Molecular Drug Targets - ANSWER-Receptors-45% Enzymes-28% Hormones-11% Unknown-7% Ion Channels-5% DNA-4% Channel-Linked (Ionotropic) Receptors - ANSWER-Produce cellular effects in milliseconds Nicotinic ACh receptor GPCRs - ANSWER-Effects happen in seconds Muscarinic ACh receptor Kinase-linked receptors - ANSWER-Effects happen in minutes Insulin receptor Receptors linked to gene transcription - ANSWER-Effects happen in hours Estrogen receptor Heterotrimeric G proteins - A...

This document consists of a summary of the course Drug Target Biochemistry and Signaling, corresponding to the Master Drug Discovery Sciences.

Question 1 2.5 / 2.5 pts Indicate whether each of the following descriptions better applies to COPI- (1), COPII- (2), or clathrin- (3) coated vesicles. Your answer would be a four-digit number composed of digits 1 to 3 only, e.g. 1322. ( ) They mediate transport from the ER to the cis Golgi network. ( ) Their coat protein forms a three-legged structure called a triskelion. ( ) They are pinched off from their donor compartment by a dynamin collar. ( ) They are involved in retrograde trans...

BERNE AND LEVY PHYSIOLOGY 7 TH EDITION KOEPPEN ALL CHAPTERS(01-44) Chapter 01: Principles of Cell FunctionTest Bank Multiple Choice 1. The subcellular structure that degrades proteins is called the: A. Tight junction B. Mitochondria C. Lysosome D. Plasma membrane E. Ribosome ANS: C 2. An experiment is done to measure the uptake of an amino acid into a cell. The following data are obtained: If Na+ is removed from the extracellular bathing solution, or if a drug is added that...

BRS PHYSIOLOGY: CHAPTER 7 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED All steroid hormones are derivatives of what common precursor? Cholesterol Thyroglublin is a derivative of... Tyrosine Epinephrine and norepinephrine are derivatives of... Tyrosine What are the two main determinants of the of a target tissue's responsiveness to a particular hormone? The number or sensitivity of receptors G proteins are active when bound to... GTP G proteins are inactive when bou...

GMS6552 EXAM 1 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED 4 receptor types in order of their speed 1. Channel-linked (inotropic) - millisecs 2. G-prot coupled rec - seconds 3. Kinase linked - minutes 4. Nuclear rec - hours What is a common example of a Channel-linked (inotropic) receptor? nicotinic ACh receptor What is a common example of a G-prot coupled receptor? Muscarinic ACh Receptor What is a common example of a Kinase linked receptor? Insulin Receptor What is a ...

MCPHS PHARMACOLOGY I FINAL EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE 2024/2025 Drug An exogenous chemical administered to alter biological/physiological process to cure/treat/prevent disease/illness Dissociation Constant (Kd) The smaller the numerical value the greater the affinity a drug has for a given receptor/drug target Transporters Moves substances into a cell Pumps Moves substances out of a cell Ion-Channels (and the two different types) Selective...

GMS 6552 CELL SIGNALING EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE Problem Set 1: Mechanisms and TGFB Which type of receptor most often utilizes second-messenger systems in its signaling? kinase-linked receptors channel-linked receptors nuclear receptors g-protein coupled receptors g-protein coupled receptors - only one that utilizes second messengers Assume you have receptor antagonists that are able to stop receptor signaling immediately. For which typ...

GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE Most common Drug Target Receptors Time frame for Channel-linked Receptors Milliseconds Class name for Channel-linked Receptors Ionotropic receptors Example of Channel-linked Receptors Nicotinic/ACh Receptors Time frame for GPCRs Seconds Class name for GPCRs Metabotropic Receptors Example of GPCRs Muscarinic/ACh Receptors Time frame for Kinase-linked Receptors Minutes Insulin receptors fall under wh...

Why is celecoxib selective for COX-2 inhibition as compared to COX-1 inhibition? COX-1 contains Ile-523, whereas COX-2 contains Val-523, which permits celecoxib binding. COX-1 contains Ile-523, whereas COX-2 contains Val-523, which blocks celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which permits celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which blocks celecoxib binding. COX-2 is located in the endoplasmic reticulum where ...