Gpcr Guides d'étude, Notes de cours & Résumés

Molecular Drug Targets - ANSWER-Receptors-45% Enzymes-28% Hormones-11% Unknown-7% Ion Channels-5% DNA-4% Channel-Linked (Ionotropic) Receptors - ANSWER-Produce cellular effects in milliseconds Nicotinic ACh receptor GPCRs - ANSWER-Effects happen in seconds Muscarinic ACh receptor Kinase-linked receptors - ANSWER-Effects happen in minutes Insulin receptor Receptors linked to gene transcription - ANSWER-Effects happen in hours Estrogen receptor Heterotrimeric G proteins - A...

This document consists of a summary of the course Drug Target Biochemistry and Signaling, corresponding to the Master Drug Discovery Sciences.

Question 1 2.5 / 2.5 pts Indicate whether each of the following descriptions better applies to COPI- (1), COPII- (2), or clathrin- (3) coated vesicles. Your answer would be a four-digit number composed of digits 1 to 3 only, e.g. 1322. ( ) They mediate transport from the ER to the cis Golgi network. ( ) Their coat protein forms a three-legged structure called a triskelion. ( ) They are pinched off from their donor compartment by a dynamin collar. ( ) They are involved in retrograde trans...

BERNE AND LEVY PHYSIOLOGY 7 TH EDITION KOEPPEN ALL CHAPTERS(01-44) Chapter 01: Principles of Cell FunctionTest Bank Multiple Choice 1. The subcellular structure that degrades proteins is called the: A. Tight junction B. Mitochondria C. Lysosome D. Plasma membrane E. Ribosome ANS: C 2. An experiment is done to measure the uptake of an amino acid into a cell. The following data are obtained: If Na+ is removed from the extracellular bathing solution, or if a drug is added that...

PHA2022 Pharmacology considers: - Pharmacotherapy: o Drug-response relationship o Selectivity of action o Structure-action relationship Lecture 1 1. Define the terms pharmacodynamics and pharmacokinetics 2. Describe (with examples) the non-specific ways in which drugs can produce therapeutic effects 3. Discuss the four specific molecular targets of drug action 4. Explain the importance of selectivity and how drugs can produce unwanted effects ONE Pharmacodynamics: how the drug acts o...

Made this summary for DRUG TARGETS BIOCHEMISTRY AND SIGNALING. Summary is detailed and complete. However, chapter 11 and 12 were not saved correctly. These are lost. I had a printed backup which is scanned and included in this summary. The quality is the same as the rest of the summary. The only thing is that it is scanned and 2 on 1 side (still readable).

Why is celecoxib selective for COX-2 inhibition as compared to COX-1 inhibition? COX-1 contains Ile-523, whereas COX-2 contains Val-523, which permits celecoxib binding. COX-1 contains Ile-523, whereas COX-2 contains Val-523, which blocks celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which permits celecoxib binding. COX-1 contains Val-523, whereas COX-2 contains Ile-523, which blocks celecoxib binding. COX-2 is located in the endoplasmic reticulum where ...

2 ways phosphate addition/removal causes conformational changes - Answer 1)Phosphorylation has a lot of negative charges that interfere with interactions between substrates --> forces protein into different conformations 2) phosphorylation of an enzyme can also alter substrate-binding affinity via electrostatic repulsion what happens to the GPCR and g-protein when a hormone reaches the GPCR receptor on cell membrane? - Answer hormone triggers a conformational change in receptor, which s...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...

Week 6 UNE Medical Biochemistry Review Exam Questions With 100% Correct Answers Glycogen is stored primarily in the: - answerliver and skeletal muscles Pathway for synthesis and degradation are identical. True or False - answerTrue Enzymes used for Glycogen synthesis - answerPhosphoglucomutase, UDPGlc pyrophosphorylase, and Glycogen synthase Glycogen synthesis - UDPGlc pyrophosphorylase: - answerGlucose 1-P + UTP → UDPGlc Glycogen synthesis - Phosphoglucomutase - answerGlucose 6-P is i...