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IMM250 CHAPTER 1-5 TOPHAT CHAPTER ONE 1. Edward Jenner’s experiment was based on his observation that dairy workers seemed immune to smallpox. He performed a famous experiment on an eight-year-old boy named James Phipps. Which of the following best describes the crucial and innovative step of...

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  • 18 januari 2023
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IMM250 CHAPTER 1-5 TOPHAT

CHAPTER ONE


1. Edward Jenner’s experiment was based on his observation that dairy workers seemed immune
to smallpox. He performed a famous experiment on an eight-year-old boy named James
Phipps. Which of the following best describes the crucial and innovative step of Jenner's
experiment and its rationale?

A: Jenner, before subjecting James to variolation, inoculated him with cowpox. Jenner thought that
persons infected with cowpox developed a form of immunity that protected them from smallpox


2. The first cholera vaccine created by Louis Pasteur is comparable to Jenner’s cowpox vaccine
because both vaccines induced immunity as a consequence of:

A: Using a less virulent form of the pathogen for inoculation

3. Emil von Behring and Shibasaburo Kitasato transferred cell-free serum from animals
immunized with diphtheria into guinea pigs that had never been exposed to diphtheria. They
were able to demonstrate:

A: All of the above

4. Many aspects of the side-chain theory of antibody formation proposed by Paul Ehrlich have
been proved correct with the exception of?

A: The idea that a single cell can express many different membrane-bound anti-toxins for different
antigens

5. Indicate in the list below the one feature that does not characterize adaptive immunity.

A: Rapid response (minutes, hours)

6. Which of the following are cells that first detect the presence of pathogens in tissues?

A: Macrophages, Dendritic cells


CHAPTER TWO

7. Koch’s postulates are:

A: Rules to be used to determine the causative agent of infectious diseases

8. Identify the incorrect statement about H. pylori infection.

A: *H. pylori* is never part of the normal microbiota

9. Ebola and SARS are examples of:

A: Emerging infections
This study source was downloaded by 100000858936669 from CourseHero.com on 01-18-2023 07:46:14 GMT -06:00


https://www.coursehero.com/file/79355052/IMM250-TOPHATdocx/

, 10. The bacterial structure attacked by defensins is:

A: Plasma membrane

11. Select the structures classified as PAMPs in the following list:

A: Endotoxin, Viral RNA, Peptidoglyca

12. Select all that apply. Binding of soluble LPS to TLR-4 requires the participation of:

A: CD14, MD-2, LBP

13. Which of the following statements concerned with PRRs is NOT true:

A: They are only expressed in leukocytes, such as macrophages or neutrophilS


CHAPTER THREE

14. Which of the following statements about macrophages is false?

A: They are found in blood

15. Indicate which of the following properties does not apply to neutrophils

A: They are tissue-resident cells

16. In neutrophils, ingested microbes are found in phagosomes and are killed by

A: All of the above

17. Type the name of the cell that releases granules containing cationic proteins toxic to parasites

A: Eosinophil

18. Which of the following changes is NOT seen at infected sites as a consequence of an acute
inflammatory response:

A: Vasoconstriction

19. During leukocyte extravasation, the role of integrins is:

A: To mediate the tight binding of leukocytes to the endothelial cells. To bind to ICAMs expressed on
endothelial cells

20. Which of the following features does not describe CRP?

A: A member of the Collectin family

21. An enzyme that can cleave C3 is

A: C3bBb

This study source was downloaded by 100000858936669 from CourseHero.com on 01-18-2023 07:46:14 GMT -06:00


https://www.coursehero.com/file/79355052/IMM250-TOPHATdocx/

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