Multiple Sclerosis Certified Specialist Exam
Questions With Complete Solutions
Relapse Remitting Multiple Sclerosis (RRMS) correct answer:
Periods of acute worsening of neurologic function, with some
degree of recovery. There is o progression in between. About
85% individuals are dx with RRMS initially
How often can remissions occur in RRMS? correct answer:
Remissions can be months to years with no new signs of disease
activity. Deficits suffered during attacks or exacerbation may
totally resolve or result in ongoing deficits.
Secondary Progressive (SPMS) correct answer: Following an
initial relapse remitting course, the disease transitions in many
people to a steadily progressive form with increased loss of
function. OF the 85% who start with RRMS, more than 50%
will develop SPMA within 10 years and 90% within 25 years.
Primary Progressive Multiple Sclerosis (PPMS) correct answer:
Continuing worsening of disease from onset, without distinct
relapses. Approximately 10% of people are dx with PPMS.
Progressive-Relapsing Multiple Sclerosis (PPMS) correct
answer: Progressive neurologic decline with occasional acute
relapses. About 5% of people appear to have PRMS at
diagnosis.
,Benign MS correct answer: Patients who have rare attacks and
are minimally disables 20 years after being diagnose with MS.
About 10% of MS patients experience a "benign course" of MS.
Radiologically Isolated Syndrome (RIS) correct answer:
Radiologically isolated syndrome (RIS) is another early
indicator of demyelination but with no symptoms. RIS is usually
detected incidentally in healthy people who have an MRI that
shows typical MS lesions. These people may remain
asymptomatic (have no symptoms), or go on to develop CIS or
MS. Therefore, RIS may represent the earliest indicator of MS
before symptoms appear.
Clinically Isolated Syndrome (CIS) correct answer: A term that
describes a first clinical episode with features suggestive of
multiple sclerosis. Usually occurs in young adults and affects
optic nerves, brainstem, or the spinal cord. They usually recover
from their presenting episode. It is often the first manifestation
of MS.
Advanced Disease correct answer:
Pediatric MS correct answer: 5% of all patients with MS
develop the disease before age of 18, 1% before the age of 10
years. Data suggests IFN Beta and glatiramer acetate are safe,
effective, and well tolerated I the pediatric population.
10 year outlook for individuals with MS
(How many utilize a cane to ambulate? What percentage require
a wheelchair? How man convert to secondary progressive phase
, of the disease? correct answer: 1/2 of patients use a cane to
ambulate
15% require a wheelchair
Approximately 1/2 of patients convert to SPMS
Multiple Sclerosis Definition correct answer: The most
common immune-mediated inflammatory demyelinating disease
of the central nervous system (CNS) - the brain, spinal cord, and
optic nerves- and is a leading cause of disability in young adults.
It is thought that the immune system attacks theCNS.
Myelin correct answer: Coating that surrounds the nerve fibers
Axons correct answer: Carry impulses away from the cell body
Nerve Fibers
How does MS get its name? correct answer: Damaged myelin
(demyelination) forms scar tissue (sclerosis) in multiple sites in
the CNS.
Immune system and how it related to cause of MS correct
answer: It may be the result of abnormal immune response to
some infectious or environmental trigger in a genetically
susceptible individual.
The pathologic process in MS begins in MS beginning with the
activation of __________in the periphery after they are
presented with a possible virus. correct answer: CD4+ T cells
What combination of cells produce an inflammatory response
and subsequent myelin damage through multiple mechanisms.
Questions With Complete Solutions
Relapse Remitting Multiple Sclerosis (RRMS) correct answer:
Periods of acute worsening of neurologic function, with some
degree of recovery. There is o progression in between. About
85% individuals are dx with RRMS initially
How often can remissions occur in RRMS? correct answer:
Remissions can be months to years with no new signs of disease
activity. Deficits suffered during attacks or exacerbation may
totally resolve or result in ongoing deficits.
Secondary Progressive (SPMS) correct answer: Following an
initial relapse remitting course, the disease transitions in many
people to a steadily progressive form with increased loss of
function. OF the 85% who start with RRMS, more than 50%
will develop SPMA within 10 years and 90% within 25 years.
Primary Progressive Multiple Sclerosis (PPMS) correct answer:
Continuing worsening of disease from onset, without distinct
relapses. Approximately 10% of people are dx with PPMS.
Progressive-Relapsing Multiple Sclerosis (PPMS) correct
answer: Progressive neurologic decline with occasional acute
relapses. About 5% of people appear to have PRMS at
diagnosis.
,Benign MS correct answer: Patients who have rare attacks and
are minimally disables 20 years after being diagnose with MS.
About 10% of MS patients experience a "benign course" of MS.
Radiologically Isolated Syndrome (RIS) correct answer:
Radiologically isolated syndrome (RIS) is another early
indicator of demyelination but with no symptoms. RIS is usually
detected incidentally in healthy people who have an MRI that
shows typical MS lesions. These people may remain
asymptomatic (have no symptoms), or go on to develop CIS or
MS. Therefore, RIS may represent the earliest indicator of MS
before symptoms appear.
Clinically Isolated Syndrome (CIS) correct answer: A term that
describes a first clinical episode with features suggestive of
multiple sclerosis. Usually occurs in young adults and affects
optic nerves, brainstem, or the spinal cord. They usually recover
from their presenting episode. It is often the first manifestation
of MS.
Advanced Disease correct answer:
Pediatric MS correct answer: 5% of all patients with MS
develop the disease before age of 18, 1% before the age of 10
years. Data suggests IFN Beta and glatiramer acetate are safe,
effective, and well tolerated I the pediatric population.
10 year outlook for individuals with MS
(How many utilize a cane to ambulate? What percentage require
a wheelchair? How man convert to secondary progressive phase
, of the disease? correct answer: 1/2 of patients use a cane to
ambulate
15% require a wheelchair
Approximately 1/2 of patients convert to SPMS
Multiple Sclerosis Definition correct answer: The most
common immune-mediated inflammatory demyelinating disease
of the central nervous system (CNS) - the brain, spinal cord, and
optic nerves- and is a leading cause of disability in young adults.
It is thought that the immune system attacks theCNS.
Myelin correct answer: Coating that surrounds the nerve fibers
Axons correct answer: Carry impulses away from the cell body
Nerve Fibers
How does MS get its name? correct answer: Damaged myelin
(demyelination) forms scar tissue (sclerosis) in multiple sites in
the CNS.
Immune system and how it related to cause of MS correct
answer: It may be the result of abnormal immune response to
some infectious or environmental trigger in a genetically
susceptible individual.
The pathologic process in MS begins in MS beginning with the
activation of __________in the periphery after they are
presented with a possible virus. correct answer: CD4+ T cells
What combination of cells produce an inflammatory response
and subsequent myelin damage through multiple mechanisms.
