Samenvatting
samenvatting laboratory animal science (BMW)
Samenvatting van het vak 'laboratory animal science', met notities van de online hoorcolleges inbegrepen. Door deze samenvatting te studeren behaalde ik een 16/20 in eerste zit.
[Meer zien]Voorbeeld 4 van de 88 pagina's
Voorbeeld 4 van de 88 pagina's
In winkelwagen1 beoordeling
Door: jhuanageboers • 4 maanden geleden
Voorbeeld van de inhoud
Legislation (1)Laboratory animal science
Numbers
- Worldwide: 100 million
- Europe: 12 million
- Belgium: 700.708
1. Rodents (81%)
2. Rabbits (9%)
3. Fish, amphibians, reptiles (5%)
4. Birds (3%)
5. Farm animals (<1%)
6. Dogs, cats, primates (<0,1%)
- Use of laboratory animals is fluctuating
└ Development of alternatives, ethics, legislation, more responsible use, high costs:
└ Development of transgenic animals:
Overview of national and European legislation
- Belgian law: august 1986
- Royal Decree: 14 november 1993 = update of the law
- New BRD: april 2010 stricter rules concerning housing
- New European Directive: september 2010 include pain, suffering, discomfort
└ The translation into belgian law is still pending
What does the law say …
Definition of laboratory = every living vertebrate animal used or intended for laboratory experiments
animal
- Including: free living and/or reproducing larval forms (axolotl)
- Excluding: other foetal or embryonic forms
- New law
└ Include some invertebrae (squid, lobster, …)
└ Include mammalian embryonic forms starting from last 1/3 of term
Definition of animal = every use of living vertebrate animal for experimental an other scientific
experiment purposes can inflict pain, suffering, discomfort or permanent injury
- Including: every treatment with the purpose/consequence of the birth of an
animal in such a condition
- Excluding: non-experimental treatments (agriculture, veterinary) + humane
methods (= least painful accepted methods to kill or mark the animal)
Animals should not be used more than once in experiments with
suffering/pain
,Degrees of pain/suffering
Mild pain - Administration anaethesia
- Non-invasive imaging (MRI)
- Superficial procedures (ear/tail biopsies)
Moderate pain - Surgery under general anaesthesia + post-surgical pain
- Induction of tumours +development spontaneous tumour
- Irradiation with sublethal dose
Serious pain - Toxicity + vaccine potency testing
- Irradiation with lethal dose
Purpose of laboratory animals
- Production + control of sera, vaccines or diagnostics
- Toxicological/ pharmacological research
- Diagnose of disease
- Education
- Answer scientific questions
Not allowed to test cosmetic products
Housing and taking care of lab animals
Detailed overview per species described in legislation
- Housing conditions, environment, space to move, feed, water and care: meet animal needs
- Daily control of animals + environment (including weekend/holidays)
- Regular control by vet
Source and identification of laboratory animals
- No stray pets, lost/abandoned animals
- Purpose-bred by licensed companies
- Farm animals
- Special demands for threatened species living in the wild
- Dogs, cats & primates
└ Marked individually and permanent
└ Immediately after weaning
- Register all animals joining & leaving the lab
Statistical information
- Handed to the government every year
└ Numbers used per species
└ Numbers per type of experiment
,Responsible use
- Experiments
└ Absolute minimum
└ Only if there is no alternative method
└ The choice of animal species must me considered
└ Lowest neurophysiological degree
- Never be subject to serious pain, great discomfort or suffering
└ If not avoided under anaesthesia
└ If anaesthesia is not possible analgesics (decrease pain)
The 3 R’s
Reduction Replacement Refinement
- Choosing well the - Replacing animal - Gathering knowledge about
experimental design experiments with another biological needs
- Standardising the lab animal method or invertebrate - Less discomfort
population and the - Environmental enrichment
experimental procedures - Apply analgesia
What to do before starting experiment
1. Laboratory license: Federal public service - Animal Welfare
└ Overview & map of the rooms
└ Overview of the kind of experiments
└ List of species and their source
└ Overview of the staff
Laboratory director = responsible manager
Expert Protection health & well-being
- Large: veterinarian
- Small: FELASCA C training
Project leader Experiment set up, log keeping
Biotechnicians Conduct experiments
Animal caretakers
2. Permission of the Ethical Committee: since 2001
└ Tasks
Evaluation of planned experiments
Setting up ethical criteria
Advising labo’s ands government
Reporting to the government
└ Professional secrecy for the members
, └ Members
Laboratory director
Project leader
Veterinarian or expert
Biotechnician
2 independent members (skills needed)
└ Apply for the permission, describe the …
Staff responsible for project
Purpose and description
Number and species of animals, degree and duration of pain
Anaesthesia and analgesia that will be used, post-operative care
Alternative methods
Humane endpoints and euthanasia
3. Education: october 2004 (FELASA)
└ Project leaders: 80h course
└ Researchers and lab technicians: 40h course
└ Animal caretakers: 25h course
Other paperwork:
4. Import license: importing animals from non-EU member states
5. Bio-security dossier
6. Radio-activity use in lab animals
Changes in legislation
- What we already had
└ Definition laboratory animal
└ Composition ethical committee
└ Continuous education
What else is there?
1. Animal welfare body
└ Set-up by every user
└ Include animal caretakers, scientist, veterinarian of expert
└ Tasks
Advise on animal welfare: accommodation, care and use
Review internal operational processes
└ Ultimate goal = improve animal welfare
Better follow-up of humane endpoints
Improve protocols ex. Anesthesia, analgesia
└ Other goal = improve transparency
Rules/laws are followed
2. More animals in the statistics: reporting all animals used in the creation of a new line
Dit zijn jouw voordelen als je samenvattingen koopt bij Stuvia:
Bewezen kwaliteit door reviews
Studenten hebben al meer dan 850.000 samenvattingen beoordeeld. Zo weet jij zeker dat je de beste keuze maakt!
In een paar klikken geregeld
Geen gedoe — betaal gewoon eenmalig met iDeal, Bancontact of creditcard en je bent klaar. Geen abonnement nodig.
Focus op de essentie
Studenten maken samenvattingen voor studenten. Dat betekent: actuele inhoud waar jij écht wat aan hebt. Geen overbodige details!
Veelgestelde vragen
Wat krijg ik als ik dit document koop?
Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.
Tevredenheidsgarantie: hoe werkt dat?
Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.
Van wie koop ik deze samenvatting?
Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper ankevanwesenbeeck. Stuvia faciliteert de betaling aan de verkoper.
Zit ik meteen vast aan een abonnement?
Nee, je koopt alleen deze samenvatting voor €6,99. Je zit daarna nergens aan vast.
Is Stuvia te vertrouwen?
4,6 sterren op Google & Trustpilot (+1000 reviews)
Afgelopen 30 dagen zijn er 64670 samenvattingen verkocht
Opgericht in 2010, al 15 jaar dé plek om samenvattingen te kopen
Laatst bekeken door jou
Tentamen (uitwerkingen) ·
NR 326 MENTAL HEALTH C Quiz 2020 – Broward College
Samenvatting ·
ATI Skills Module - Nasogastric Tube ( latest update )
Tentamen (uitwerkingen) ·
NURS 6521 Week 8 Quiz – Question and Answers
Samenvatting ·
ANALYSIS OF CHINESE SOURCES AND ESSAY PLAN
Overig ·
HESI A2 Anatomy and Physiology Study Guide
Samenvatting ·
Strafrecht - Deel 2, hoofdstuk 2 (het misdrijf)
Samenvatting ·
Samenvatting reader trampoline springen 3LO
Samenvatting ·
Synthèse d'introduction au droit judiciaire
