Summary human diseases including lectures/notes and ppt for the English biomedical Master.
It is a draft version, meaning that everything is in it, but lay-out has not been properly checked. Will upload the new version as soon as possible.
Human disease
Please note that this is a draft, I refine it and upload later
The emphasis will be on the clinical practice of diagnosis and therapy, rather than on the scientific
basis to understand disease processes
Inhoudsopgave
Lung disease- C. Dubois.........................................................................................................................4
Lung diseases affecting the airways....................................................................................................6
Asthma............................................................................................................................................6
Chronic obstructive pulmonary disease (COPD)............................................................................7
Emphysema.....................................................................................................................................7
Acute and Chronic bronchitis.........................................................................................................7
Cystic fibrosis.................................................................................................................................8
Lung disease affecting the alveoli.......................................................................................................8
Pneumonia......................................................................................................................................8
Tuberculosis..................................................................................................................................10
Emphysema: resulting from damage to fragile connections between alveoli................................12
Pulmonary edema.........................................................................................................................12
Lung cancer..................................................................................................................................13
Pneumoconiosis............................................................................................................................14
Lung diseases affecting the interstitium............................................................................................14
Sarcoidosis....................................................................................................................................15
Other lung diseases...........................................................................................................................16
Vascular diseases- C. Dubois................................................................................................................17
Arteriosclerosis.................................................................................................................................17
Atherosclerosis..............................................................................................................................17
Aneurysms........................................................................................................................................20
Dissection.........................................................................................................................................22
Aortitis/vasculitis..............................................................................................................................22
Venous disorders...............................................................................................................................22
Deep vein thrombosis....................................................................................................................22
Pulmonary embolism....................................................................................................................23
Chronic venous insufficiency and post-phlebitic syndrome...........................................................24
Superficial venous thrombosis: Phlebitis......................................................................................24
Varicose veins...............................................................................................................................24
Coronary artery disease, ECG basics and arrhythmias- C. Dubois.......................................................25
Coronary artery disease....................................................................................................................25
, ECG basics.......................................................................................................................................28
Heart Failure and Valve Diseases- C. Dubois.......................................................................................29
Heart failure......................................................................................................................................29
Valve Disease....................................................................................................................................34
Carditis and Congenital heart disease- C. Dubois.................................................................................35
Carditis.............................................................................................................................................35
Endocarditis..................................................................................................................................35
Myocarditis...................................................................................................................................37
Pericarditis...................................................................................................................................37
Congenital heart disease...................................................................................................................38
Gastroenterology- H. van Malenstein...................................................................................................39
Esophagus.........................................................................................................................................39
Reflux disease...............................................................................................................................40
Barrett esophagus.........................................................................................................................41
Extra’s...........................................................................................................................................42
Stomach............................................................................................................................................43
Gastritis........................................................................................................................................44
Peptic ulcer disease......................................................................................................................44
Extra’s...........................................................................................................................................45
Small bowel......................................................................................................................................46
Celiac disease...............................................................................................................................47
Appendicitis..................................................................................................................................47
Colon................................................................................................................................................48
Constipation.................................................................................................................................48
Polyps...........................................................................................................................................49
Diverticular disease......................................................................................................................49
Clinical syndromes...........................................................................................................................50
Acute abdomen.............................................................................................................................50
Diarrhea.......................................................................................................................................52
GI bleeding...................................................................................................................................53
Inflammatory bowel disease (IBD)...............................................................................................54
Irritable bowel syndrome (IBS).....................................................................................................55
Biliary disease..............................................................................................................................56
Hepatology- H. van Malenstein............................................................................................................58
Liver anatomy and function..............................................................................................................58
Assessment of the liver.....................................................................................................................58
Hepatitis...........................................................................................................................................59
, Alcohol..........................................................................................................................................60
Fatty liver.....................................................................................................................................60
Viral hepatitis...............................................................................................................................61
Other.............................................................................................................................................62
Acute liver failure.............................................................................................................................62
Cirrhosis...........................................................................................................................................63
Portal hypertension......................................................................................................................63
Other complications......................................................................................................................64
Transplantation.............................................................................................................................66
Oncology- H. van Malenstein...............................................................................................................66
Pathophysiology...............................................................................................................................67
Clinical oncology..............................................................................................................................68
Cancer types.....................................................................................................................................71
Breast cancer................................................................................................................................71
Prostate cancer.............................................................................................................................73
Lung cancer..................................................................................................................................73
Colorectal cancer.........................................................................................................................74
Pancreatic cancer.........................................................................................................................75
Nephrology- K. Claes...........................................................................................................................77
Kidney basics...................................................................................................................................77
Renal syndromes..............................................................................................................................79
Nephrotic syndrome......................................................................................................................79
Acute kidney injury.......................................................................................................................80
Chronic kidney disease and complications...................................................................................81
Glomerular disease...........................................................................................................................83
Membranous nephropathy............................................................................................................84
Hereditary renal disease....................................................................................................................85
ADPKD.........................................................................................................................................85
Alport disease...............................................................................................................................86
Drugs and the kidney........................................................................................................................86
Tubular toxicity.............................................................................................................................87
Acute interstitial nephritis (also non drugs)..................................................................................88
Hemodynamically mediated nephrotoxic acute renal failure........................................................89
Onconephrology (all of the above)................................................................................................90
Nephrolithiasis- K. Claes......................................................................................................................90
Endocrinology- K. Claes......................................................................................................................91
Introduction......................................................................................................................................91
, Thyroid disorders..............................................................................................................................92
Normal function and anatomy......................................................................................................92
Hypothyroidism.............................................................................................................................92
Hyperthyroidism...........................................................................................................................94
Nonthyroidal illness......................................................................................................................96
Thyroid nodules/ goiter/ thyroid cancer........................................................................................96
Diabetes............................................................................................................................................97
Obesity.............................................................................................................................................99
Hypertension- K. Claes.......................................................................................................................100
Secondary hypertension..................................................................................................................101
Rheumatoid arthritis- K. de Vlam.......................................................................................................102
Introduction: joint anatomy and biology.........................................................................................102
Rheumatoid arthritis (RA)..............................................................................................................103
Spondylarthritis- K. de Vlam..............................................................................................................106
Axial SpA- AS................................................................................................................................106
Pathology and causes of SpA..........................................................................................................108
Diagnosis and treatment of SpA.....................................................................................................108
Osteoporosis- K. de Vlam...................................................................................................................109
Osteoarthritis- K. de Vlam..................................................................................................................112
Skin diseases- K. de Vlam..................................................................................................................114
Psoriasis..........................................................................................................................................114
Other skin diseases.........................................................................................................................116
Neurological diseases- K. de Vlam.....................................................................................................117
Parkinson’s disease.........................................................................................................................117
Multiple sclerosis............................................................................................................................119
Amyotrophic lateral sclerosis.........................................................................................................121
Lung disease- C. Dubois
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