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USMLE STEP 1 IMMUNOLOGY FINAL EXAM 2025/2026 QUESTIONS WITH ANSWERS GRADED A+

A 63-year-old woman comes to the physician because of a 2-week history of fatigue, malaise, nausea and vomiting, and decreased appetite; these symptoms have worsened during the past week. She was diagnosed with tuberculosis 3 months ago; a multidrug regimen was initiated at that time. Her temperature is 37.1°C (98.8°F). Physical examination shows scleral icterus and tenderness over the right upper quadrant of the abdomen; there is no hepatomegaly. Serum studies show a total bilirubin c...

What microbes stain with Silver Stain? - Fungi - pneumocystis (PCP in AIDS patients) Legionella (silver haired men at American Legion) H. pylori What media grows for H. influenzae? - Chocolate agar (has Factor V [NAD+] and Factor X [hematin]) What media grows Neisseria (gonorrhea, meningitidis) - Thayer-Martin agar has various antibiotics to inhibit growth of everything but Neisseria Vancomycin (inhib Gm +) Trimethoprim, Colistin (inhib Gm-) Nystatin (inhib fungi)

Warburg Effect - malignant cells undergo high rates of glycolysis to produce macromolecules necessary to sustain rapid cellular growth Risk Factors of Endometritis - -C-section delivery -chorioamnionitis -group B strep colonization -intrauterine instrumentation -preterm delivery -prolonged labor -prolonged ruptured membranes -retained products of conception SIGNS AND SX OF POSTPARTUM ENDOMETRITIS -fever -leukocytosis -uterine tenderness -foul smelling vaginal discharge

What type of Antibiotics inhibit bacterial topoisomerase 4? - Quinolones _____chormatin is tightly coiled and transcriptionally inactive while _____chromatin is less condensed and is transcriptionally active. - Heterochromatin; Euchromatin DNA methylation often ______ genes while histone acetylation ______. - Inactivates (decreases gene transcription); Loosens DNA making it more accessible and more easily transcribed. Sjogren's syndrome (lymphocytic infiltration of salvivary and lacrima...

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