Conjugates - Study guides, Class notes & Summaries

The purpose of phase 1 was to produce metabolites with functional groups or ________ _____________ correct answer: chemical handles The purpose of phase 2 is to introduce glucuronic acid, sulfate ions, acetyl groups, amino acids, or methyl groups with the goal of generating a hydrophilic conjugate for ________________. correct answer: excretion What are the most important conjugation enzymes? correct answer: UDP glucuronoyltransferases (UGTs), sulfotransferases (STs), glutathione S-tran...

Which one of the following statements about acetaminophen metabolism is false? Choose the single best answer A. It is metabolized in the kidney B. It is largely metabolized in the liver to glucuronide and sulfonate conjugates C. A small amount is metabolized via cytochrome oxidase to a reactive benzoquinoneimine intermediate D. This intermediate becomes toxic to the liver once tissue glutathione becomes depleted - ANSWER-A; The benzoquinoneimine intermediate produced in the liver as a...

there is a decrease in products - if K <<<< 1 of a weak acid, then (concerning products) decrease in pH - an increase in K and products will result in (concerning pH) Ka - equilibrium constant for ionization of acid increases - if the percent ionization increases, what happens to acid strength? K decreases - what happens to K as you deprotonate acids? weaker - do acid become weaker or stronger as you deprotonate them? no - do SA/SB have conjugates?

Complete Solutions Manual for Galois Theory, 5th Edition by Ian Stewart ; ISBN13: 9781032101583. (Full Chapters included Chapter 1 to 26)....1. Classical Algebra. 1.1. Complex Numbers. 1.2. Subfields and Subrings of the Complex Numbers. 1.3. Solving Equations. 1.4. Solution by Radicals. 2. The Fundamental Theorem of Algebra. 2.1. Polynomials. 2.2. Fundamental Theorem of Algebra. 2.3. Implications 3. Factorisation of Polynomials. 3.1. The Euclidean Algorithm. 3.2 Irreducibility. 3.3. Gauss’s Le...

1 day old bilirubin 14, direct 0.5? - CORRECT ANSWER-Pathologic Jaundice (>12, direct >2, day of life I, fast rate of rise >5/day). Next best test is a Coombs test (+ means Rh or ABO incompatibility; - indicated maternal fetal transfusion, twin/twin trasfusion, IDM, spherocytosis I week old baby with cyanosis when feeding but pinks up when crying? - CORRECT ANSWER-Choanal Atresia - Restricted nasal passages (choana). Associated with CHARGE syndrome (Coloboma, Heart defects, Atresia c...

Which one of the following statements about acetaminophen metabolism is false? Choose the single best answer A. It is metabolized in the kidney B. It is largely metabolized in the liver to glucuronide and sulfonate conjugates C. A small amount is metabolized via cytochrome oxidase to a reactive benzoquinoneimine intermediate D. This intermediate becomes toxic to the liver once tissue glutathione becomes depleted A; The benzoquinoneimine intermediate produced in the liver as a result o...

Pharmacology Ch. 31 Opioid Analgesics & Antagonistswhat are the major therapeutic uses of opioid drugs? - correct answer analgesics antitussives antidiarrheal what are partial opioid agonists? what is the prototype of a strong analgesic or full agonist? - correct answer -partials exert less analgesia than morphine -morphine is the prototype which drugs undergo extensive 1st pass metabolism? - correct answer morphine hydromorphone oxymorphone what is an opiate? - correct answer drug deriv...

Acetaminophen (APAP) toxicity is mediated by _________ . saturated normal liver conjugation pathways followed by insufficient glutathione to conjugate the metabolite NAPQI, which binds to hepatocellular proteins causing oxidative damange, mitochondrial dysfunction, and hepatocellular death What is the first step in acute overdose of acetaminophen? Metabolism by conjugation becomes saturated, and excess APAP is oxidatively metabolized by the CYP enzymes (CYP2E1, 1A2, 2A6, and 3A4) to t...

***Download Test Bank Immediately After the Purchase. Just in case you have trouble downloading, kindly message me, and I will send it to you via Google Doc or email. Thank you*** PHA 6432 - Fundamentals of Pharmaceutical Chemistry is a foundational course that provides an introduction to the principles of pharmaceutical chemistry, including an understanding of drug structure and its importance in the drug discovery and development process. This course is designed to equip students with knowled...

RTK in NGF One ligand binds 2 receptors causing dimerization + phosphorylation at tyrosine residues. Monomers phosphorylate each other + can activate effectors downstream. RTK in Insulin Receptors 2 ligands each bind receptors on the alpha side, causing conformational change to each alpha-beta pair. The beta subunits phosphorylate each other and can activate effectors downstream. Female Sexual Differentiation 1. Ovaries develop from cortex while medulla regresses 2. Wolffian du...