Gms6504 2 - Study guides, Class notes & Summaries

GMS6504 Exam 2 Questions And Accurate Answers...

GMS6504 exam 2 questions with correct answers

GMS6504 Exam 2 Questions And Answers With Real Tests What are the 4 things that make something a good drug? ANS 1. Lipinski's Rule of 5 2. Chemical reactivity: good or bad? 3. Some chemically or biologically reactive functional groups to recognize 4. Choosing a target What is Lipinski's Rule of 5? ANS 1.Molecular mass greater than 500 Da 2.High lipophilicity (expressed as LogP greater than 5) 3.More than 5 hydrogen bond donors 4.More than 10 hydrogen bond acceptors Par...

GMS6504 Exam 2 Questions And Correct Answers Graded A+...

GMS6504 Exam 2 Questions And Answers In terms of Lipinski's rules, which of the following functional groups serves as a hydrogen bond donor? ANS -NH2 Will a hydrophobic molecule have a high or low logP? ANS high Which is the best explanation as to why CNS drugs tend to have smaller polar surface areas than drugs that target things outside of the CNS? ANS It helps the drug cross the blood brain barrier Which functional group is most often utilized when making pro-drugs? ANS Ester...

GMS6504 Exam 2 Questions With Correct Answers What 4 factors determine whether a drug is good or bad? - answer1. Lipinski's Rule of 5 2. Chemical Reactivity: Good or bad 3. Functional Groups 4. Drug Targets Name atleast 3 Lipinski's Rules (Basic) - answer1. Molecular mass greater than 500 Da 2. High Lipophilicity, LogP greater than 5 3. More than 5H bond donors (FH,NH,OH) 4. More than 10H bond acceptors (O,F,N) When we have high values of Lipinski's Rules of 5. what does this tell u...