Cetuximab - Study guides, Class notes & Summaries

NR565 MIDTERM, WEEK 4 EXAMINABLE QUESTIONS AND ANSWERS, GRADED A+ what makes clopidogrel unique among other P2Y12 inhibitors? - -relies on cytochrome P450 enzyme to convert into active metabolite (CYP2C19) thus requiring this gene to be present to be an effective drug in clot formation Alternatives to clopidogrel - -Brilinta (ticagrelor) or Effient (Prasugrel) because they are not dependent on CYP2C19 genotype Name the 4 medications that REQUIRE pharmacogenetic testing - -Cetuximab, t...

True or False? Bevacizumab blocks angiogenesis and is therefore associated with quicker wound healing. Correct Answer False True or False? Cetuximab is associated with acneform rash, which may lead to delay in doses or discontinuation of the drug for recurrent episodes. Correct Answer True True or False? Denosumab is used to prevent skeletal-related events due to bone mets from solid tumors. Correct Answer True True or False? Denosumab can be used in managing skeletal-related events due...

ONS Chemotherapy Immunotherapy Certificate exam with 100% correct Answers 2023 3 major phases of cell division: - Correct Answer-Interphase Mitotic phase Cytokinesis 3 steps of interphase: - Correct Answer-First growth phase (G1) Synthesis phase (S phase) Second growth phase (G2) 4 phases of mitosis: - Correct Answer-Prophase Metaphase Anaphase Telophase Innate immunity: - Correct Answer-Non-specific response, either: 1. Barrier (skin, mucous membranes, flora of skin/gut) 2. Cellu...

Bortezomib correct answer: (Velcade) IV or SQ -green tea should be avoided while taking this drug, especially in liquid and capsule forms -CYP3A4 inhibitors or inducers may alter drug activity, monitor closely Capecitabine correct answer: Xeloda Oral directions: take within 30 mins of a mealw/full glass of water -altered coagulation when taken with Warfarin, monitor closely -Vitamin B6 (50-100mg 2-3x/day) may help to prevent/reduce the incidence and severity of foot/hand syndrome ...

Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: Question options: A need to monitor drugs metabolized by 2D6 for toxicity Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors Decreased conversion of codeine to morphine by CYP 2D6 The need for lowered dosages of drugs, such as beta blockers - Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors Rifampin is a nonspeci...

Pharm Exam Questions And Answers (Verified And Updated) A provider considers prescribing tamoxifen for a woman with breast cancer. Upon reviewing results of genetic testing, the prescriber notes that the patient has variations in the CYP2Dyallele resulting in a deficiency of the CYP2D6 isoenzymes. What action will this deficiency warrant in the prescribing of tamoxifen, a CYP2D6 substrate? A. The tamoxifen will not be prescribed. B. The individual doses of tamoxifen will be increased. C....

Chapter 1. An Introduction to Pharmacogenetics Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Genetic polymorphisms account for differences in metabolism, including: • Poor metabolizers, who lack a working enzyme • Intermediate metabolizers, who have one working, wild-type allele and one mutant • Extensive metabolizers, with two normally functioning alleles • All of the above 2. Up to 21% of Asians are ultra-rapid 2D6 metab...

NR565 midterm, week 4 Exam Questions and Answers what makes clopidogrel unique among other P2Y12 inhibitors? - Answer-relies on cytochrome P450 enzyme to convert into active metabolite (CYP2C19) thus requiring this gene to be present to be an effective drug in clot formation Alternatives to clopidogrel - Answer-Brilinta (ticagrelor) or Effient (Prasugrel) because they are not dependent on CYP2C19 genotype Name the 4 medications that REQUIRE pharmacogenetic testing - Answer-Cetuximab, tra...

Prescribing basics Correct Answer Prescribing is regulated by state BON Proper RX Correct Answer Providers name and address, Telephone DEA Pt name/DOB/Addres Name of Drug, strength, SIG(directions) with indication/Route and frequency, Quantity and signature. Drug Schedules: Most addictive to least Correct Answer 1: Heroin,LSD, MJ 2: hydrocodone, cocaine, Methamphetamine, methadone, oxycodone, meperidine, fentanyl, adderall, ritalin 3: codeine, ketamine, testosterone 4: xanax, valium,...

Oxaliplatin - Answer- NEUROTOXICITY AVOID COLD (neuropathies exacerbated by cold exposure) Dilute with D5W* Cyclophosphamide - Answer- HEMMORRAGHIC CYSTITIS Blood in urine -> fluids (sometimes Mesna) Temazolamide - Answer- Headache (crosses into CNS)*** Interferons - Answer- ACUTE: Flu-like Syndrome CHRONIC: Depression- BLACK BOX WARNING Interleukin-2 - Answer- Flu-like Syndrome Capillary Leak Syndrome Cabazitaxel - Answer- No PVC bags or tubing! Docetaxel - Answer- No PVC bags or ...