Lipinskis rules - Study guides, Class notes & Summaries

GMS6504 #2 Questions And Answers With Verified Solutions what are the four things that make a good drug versus a bad one? 1. Lipinski's Rule of 5 2. Chemical reactivity: good or bad? 3. Some chemically or biologically reactive functional groups to recognize 4. Choosing a target explain the old lipinskis rule of 5 and the rules Poor absorption or permeation are more likely when: 1. Molecular mass greater than 500 Da (want small and absorbable) 2. High lipophilicity (expressed as LogP...

Medicinal Chemistry Exam Review Solution Lipinski's Rules - ANS-An orally active drug should have the following: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular weight under 500 Da An octanol-water partition coefficient less than 5 First Pass Effect - ANS-When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must either increase ...

GMS6504 Exam 2 Questions And Accurate Answers...

GMS 6504 Review Exam 2 Questions And Answers With Complete Updates In terms of Lipinski's rules, which of the following functional groups serves as a hydrogen bond donor? A. -Cl B. -NO2 C. =O D. -SO3 E. -NH2 E. -NH2 Will a hydrophobic molecule have a high or low logP? A. High B. Low A. High Which is the best explanation as to why CNS drugs tend to have smaller polar surface areas than drugs that target things outside of the CNS? A. The receptors in the CNS tend to be small prot...

GMS6504 Exam 2 Questions And Answers In terms of Lipinski's rules, which of the following functional groups serves as a hydrogen bond donor? ANS -NH2 Will a hydrophobic molecule have a high or low logP? ANS high Which is the best explanation as to why CNS drugs tend to have smaller polar surface areas than drugs that target things outside of the CNS? ANS It helps the drug cross the blood brain barrier Which functional group is most often utilized when making pro-drugs? ANS Ester...

Medicinal Chemistry, Exam Elaboration 2024. Lipinski's Rules - Indicate: An orally active drug should have the following: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular weight under 500 Da An octanol-water partition coefficient less than 5 First Pass Effect - Indicate: When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must e...