Lipinskis rules - Study guides, Class notes & Summaries
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Medicinal Chemistry Exam Review Solution
- Exam (elaborations) • 18 pages • 2023
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Medicinal Chemistry Exam Review Solution 
Lipinski's Rules - ANS-An orally active drug should have the following: 
No more than 5 hydrogen bond donors 
No more than 10 hydrogen bond acceptors 
A molecular weight under 500 Da 
An octanol-water partition coefficient less than 5 
First Pass Effect - ANS-When the majority of the active drug is metabolized the first time it goes through 
the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must either 
increase ...
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GMS6504 Exam 2 Questions And Accurate Answers
- Exam (elaborations) • 11 pages • 2024
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GMS6504 Exam 2 Questions And Accurate Answers...
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Medicinal Chemistry, Exam Elaboration 2024.
- Exam (elaborations) • 12 pages • 2024
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Medicinal Chemistry, Exam Elaboration 2024. 
 
Lipinski's Rules - Indicate: An orally active drug should have the following: 
No more than 5 hydrogen bond donors 
No more than 10 hydrogen bond acceptors 
A molecular weight under 500 Da 
An octanol-water partition coefficient less than 5 
 
First Pass Effect - Indicate: When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must e...
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