Complement plays a role in which hypersensitivity - ✔ ✔ type 2 and type 3
Describe the size of the immediate reaction to an allergen and the late phase reaction - ✔ ✔ -
immediate is very confined and localized
-late-phase is very broad
How does corticosteroids reduce asthma - ✔ ✔ -it inhibits the formation of amines, TNF, IL-4, IL-5
and other cytokines to reduce inflammation
How does Cromolyn reduce asthma? - ✔ ✔ it inhibits mast cell degraulation that leads to bronchial
constriction
How does sensitization work in type 1 hypersensitivity? - ✔ ✔ -each successive exposure to an
allergen produces more IgE
-this IgE replaces other allergen specific IgE on mast cells
-each exposure causes more mast cells to be primed for the next exposure
In what two situations can hypersensitivity occur (broad definition) - ✔ ✔ -uncontrolled response to
foreign antigen
-failure of self-tolerance
Type 1 mast degranulation in GI can cause - ✔ ✔ intestinal hypermotility
Type 1 mast degranulation in the lungs causes - ✔ ✔ broncho-constriction
Type 1/2/3 hypersensitivity are mediated by - ✔ ✔ antibodies
Type 4 hypersensitivity is mediated by - ✔ ✔ T cells
What are the characteristics of allergens that contribute to a hypersensitivity reaction - ✔ ✔ -
proteins
-enzymatically active protease
-low dose = favors IL-4 producing T cells
-highly soluble
Describe the size of the immediate reaction to an allergen and the late phase reaction - ✔ ✔ -
immediate is very confined and localized
-late-phase is very broad
How does corticosteroids reduce asthma - ✔ ✔ -it inhibits the formation of amines, TNF, IL-4, IL-5
and other cytokines to reduce inflammation
How does Cromolyn reduce asthma? - ✔ ✔ it inhibits mast cell degraulation that leads to bronchial
constriction
How does sensitization work in type 1 hypersensitivity? - ✔ ✔ -each successive exposure to an
allergen produces more IgE
-this IgE replaces other allergen specific IgE on mast cells
-each exposure causes more mast cells to be primed for the next exposure
In what two situations can hypersensitivity occur (broad definition) - ✔ ✔ -uncontrolled response to
foreign antigen
-failure of self-tolerance
Type 1 mast degranulation in GI can cause - ✔ ✔ intestinal hypermotility
Type 1 mast degranulation in the lungs causes - ✔ ✔ broncho-constriction
Type 1/2/3 hypersensitivity are mediated by - ✔ ✔ antibodies
Type 4 hypersensitivity is mediated by - ✔ ✔ T cells
What are the characteristics of allergens that contribute to a hypersensitivity reaction - ✔ ✔ -
proteins
-enzymatically active protease
-low dose = favors IL-4 producing T cells
-highly soluble
