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Mumps Virus Notes
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Lecture notes study book Medical Microbiology of Michael R. Barer, Will L. Irving, Nelun Perera (Chapter 46 ) - ISBN: 9780702072000 (Q&S based)
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L6 Mumps VirusWhat is mumps virus (MuV)?
A virus causing mumps disease. It contains a ss-Negative Sense-RNA genome. The genome is 15,000
Nucleotides in lengths, and contains 7 genes encoding for 9 proteins. Moreover, the genome is enclosed
within a capsid that is surrounded by a viral envelope.
MuV particles (Virions) are pleomorphic in shape and vary in size from 100 to 600nm
How many serotypes of MuV are available?
1 serotype and 12 genotypes that vary in geographic distribution are available.
Who is the natural host of mumps virus?
Humans
What family does mumps virus belong to?
Paramyxoviridae which includes paramyxoviruses.
What are the 2 surface glycoproteins found in paramyxoviruses?
- Hemagglutinin: neuraminidase
- Fusion proteins
What are paramyxoviruses sensitive to?
- Heat
- UV light
What are the common features of mumps virus?
It is the most common cause of parotid gland enlargement in children. Furthermore, in severe cases,
mumps virus can cause orchitis and aseptic meningitis.
Explain the pathogenesis of mumps virus:
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