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(Solution) NURS 6630 week 2 Discussion: Foundational Neuroscience CA$15.35   Add to cart
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(Solution) NURS 6630 week 2 Discussion: Foundational Neuroscience
  • Course
  • NURS 6630
  • Institution
  • Walden University

(Solution) NURS 6630 week 2 Discussion: Foundational Neuroscience As a psychiatric nurse practitioner, it is essential for you to have a strong background in foundational neuroscience. In order to dia gnose and treat patients, you must not only understand the pathophysiology of psychiatric disorder...

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  • July 27, 2022
  • 4
  • 2021/2022
  • Other
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  • discussion
  • solution nurs 6630 week 2 discussion foundational neuroscience

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  • Walden University
  • NURS 6630
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Explain the agonist-to-antagonist spectrum of action of
psychopharmacologic agents, including how partial and inverse agonist
functionality may impact the efficacy of psychopharmacologic
treatments.

The traditional drug-receptor theory is a concept of how drugs abide, drug-

receptor interaction, and agonists' actions and antagonists with affinity and intrinsic

efficacy (Berg, & Clarke, 2018). Berg and Clark's study of the theory found that drugs

can act as antagonists or agonists. In contrast, agonists drugs have intrinsic efficacy and

affinity, and antagonists have only relationship and no inherent effectiveness. The authors

noted that the antagonists decrease the probability of agonist drug occupancy by

occupying the receptor cells. Still, the increased agonist concentration leads to the agonist

increasing receptor occupancy, thus blocking antagonists' effects. A full agonist generates

the maximal response a system is capable whereas a partial agonist produces a

submaximal reaction; However, a partial agonist's intrinsic efficacy is less than that of a

full agonist; full agonists can also differ in inherent efficacy. Lastly, the spare receptors or

receptor reserve is the ability of an agonist can produce a maximum response without

occupancy of the entire receptor population due to saturation of post-receptor signaling

mechanisms,


Compare and contrast the actions of g couple proteins and ion gated channels.

Ion gated receptors have a key role in the nervous system for signaling, allowing

rapid and conversion of chemical neurotransmitter messages to electrical current with ionotropic

receptors regulated by protein-protein interactions with other ion channels, G-protein coupled

receptors and intracellular proteins (Li et al., 2014). Li et al. found that the G Protein interactions

with ion channel receptors can increase the capacity of neuronal signaling cascades and represent


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