ASCP MLS Hematology/Coagulation practice QUESTIONS WITH COMPLETE SOLUTIONS

Prostacyclin Correct Answer: produced by the walls of endothelial cells and prevents formation of the platelet plug involved in primary hemostasis by preventing platelet activation and aggregation as well as inducing vasodialation. Epinephrine Correct Answer: agonist used in platelet aggregation studies ristocetin Correct Answer: causes platelets to bind to vWF via their GPIb receptor. A test is abnormal in a vWF deficiency since the platelets cannot bind, which causes lack of adhesion/aggregation Thromboxane A2 Correct Answer: it stimulates activation of new platelets as well as increases platelet aggregation, produced by platelets Vitamin K dependent factors Correct Answer: II, VII, IX, X Tumor cell clump Correct Answer: CSF from a cytospin Prevous subarachnoid Hemorrhage Correct Answer: CSF: xanthochromia; dark granular, iron-laden hemosiderin deposits (blue arrows); yellow crystalline, iron-free hemotiodin crystals (red arrows) in macrophages Glanzmann thrombasthenia Correct Answer: Due to a genetic GPIIb/IIIa deficiency; platelet aggregation is impaired Von Willebrand Disease Correct Answer: bleeding disorder caused by a deficiency of von Willebrand factor, a "sticky" protein that lines blood vessels and reacts with platelets to form a plug that leads to clot formation Aspirin therapy Correct Answer: inactivates Thromboxane A2 which binds to platelet receptor TPa Bernard-Soulier syndrome Correct Answer: genetic GPIB deficiency; platelet ADHESION impaired, blood smear shows thrombocytopenia with enlarged platelets. enlarged because they are slightly more immature deficient in platelet receptor Ib/IX/V which binds to VWF Neutrophil maturation sequence Correct Answer: Myeloblast promyelocyte myelocyte metamyelocyte (juvenile) Band (stab) segmented neutrophil (PMN)