Summary

Summary PSL372 Action Potential Prelab Notes

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Course
PSL372

Institution
University Of Toronto (U Of T )

Ion channels, membrane potential, action potential, gating of voltage-dependent channels, refractory period, ion conductance and permeability, depolarization block, drugs

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Uploaded on December 9, 2022
Number of pages 4
Written in 2022/2023
Type Summary

action potential
m gate
n gate
h gate
depolarization block
resting membrane potential
tetrodotoxin ttx
tetraethylammonium tea
barium ba2

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372 CAB01 Action Potential
PSL

on channels
specializedmacromoleculartransmembraneproteins
importantforbidirectionaltransportof lipidinsolubleions
requiredto generate
11 membranepotential dmaintaincellvolume
excitablea nonexcitablecells
21 actionpotentials excitablecells
s importantproperties
in ionconduction rapidrateacrossmembrane
21 selectivity ion specificity
31 gating openclosetospecificstimuli
voltagegatedligandgated mechanically gated

Membrane Potential cum definedrelativetocellexterior
dependson
D iondistributionacrossmembrane Ict Nat l l canbedescribedbyGoldman Hodgkin Katz eq
Membranepemeabilitytodifferentions y Um It
Kt o Pna that lot paler
In Pic
p piety t pna that sit PatelJi

iii
at restingmp.hr
membraneismostlypermeableto k t cplat p pNat
man
Inotvoltagegated voltagerequiredto maintaina particular is gradient
Kt Nat
Ewat t60mV
Cl outside
Ext goMV
11 kt ions Ear 70mV inside

since Kt s E KtJo Kttravelsoutward Iet out
KY
insidebecomesmorenegativerelative to outside redarrows Ex
Eventually Iactout Iactin duetoelectricalgradient
equilibriumpotential cent somv Rmp 70mV
4 depictedby Nernstear
in ex o
Ex
II ex

21 Nations
Natso s Nat
inwardNatcurrent
wever permeability to wat cats is
antetype

si et ions
TenTo s tri
pet isverysmall
Targe c
ilychafedproteinsinsidecellkeeps a
ionsoutside

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