BCPS Pharmacokinetics| 150 QUESTIONS| WITH COMPLETE SOLUTIONS
What is the calculation for bioavailability (F)? correct answer: F = [(IV dose x AUC of oral dose)/(Oral dose x AUC of IV dose)] What is the calculation to determine Vd of a rapidly administered IV bolus (or oral dose)? correct answer: Vd = (F x dose)/C C = initial concentration What is the calculation to determine Vd for a continuous infusion at steady state? correct answer: Vd = R/(k x Css) R = Initial infusion rate k = elimination constant Css = steady state concentration How can you calculate clearance for continuous IV infusion before steady state? correct answer: Clearance = (Ro/C) * (1 - e^ -kti) ti = time since infusion started Ro = rate of infusion How is the clearance of a drug calculated? correct answer: Clearance = Dose/AUC How is k (elimination constant) related to clearance (Cl) and Vd? correct answer: k = Cl/Vd Expressed another way: Cl = k * Vd How can you calculate k (elimination constant) from two known concentrations? correct answer: k = (lnC1 - lnC2)/(t2 - t1) How can you calculate half life (t 1/2) from
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bcps pharmacokinetics| 150 questions| with complete solutions
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