Summary
Summary Drugs Used in Diabetes and Clinical Trials
- Course
- PHARM 223 (PHARM222)
- Institution
- University Of Waterloo (UW )
Summary table of the drugs used in diabetes and their corresponding clinical trials
[Show more]
Seller
Follow
Content preview
Name Type of Trial Main Intervention Control Main Findingspopulation
studied
FDPS Diabetes Pre – diabetic Lifestyle Usual care
Prevention Middle age
DPP Diabetes Pre – diabetic Lifestyle or Placebo Metformin reduced incidence of developing TDM.
Prevention Middle age Metformin Lifestyle > metformin
STOP- Diabetes Pre – diabetic Acarbose Placebo
NIDDM Prevention Middle age
XENDOS Diabetes Pre – diabetic Orlistat Placebo GI ADR >91%
Prevention Middle age
DREAM Diabetes Pre – diabetic Rosiglitazone Placebo NNT 7.5 over 3 years
Prevention Middle age
CANOE Diabetes Pre – diabetic Rosiglitazone Placebo
Prevention Middle age + Metformin
ACT-NOW Diabetes Pre – diabetic Pioglitazone Placebo
Prevention Middle age
DCCT Glucose T1DM MDI insulin or 1-2 Insulin Intensive BG control reduced micro and macro and all
(F/U Study Control Trial Late 20s CSII Inj per day cause mortality (50-60%)
EDIC) (3 or more) 50% reduction in microvascular complications over 6 years with
intensive glycemic lowering regime
Reduction in albuminuria (DCCT/EDIC)
Reduced LT risk of impaired GFR (EDIC)
UKPDS 33 Glucose T2DM (new) SU’s or Insulin Diet CVD neutral but decreased over LT f/u
Control Trial & Middle age (Intensive) Reduced micro
Drug Control Insulin decreased A1C significantly
Trial (Insulin) Weight gain + risk of hypo
UKPDS 34 Glucose T2DM (new Metformin Diet CVD neutral but decreased over LT 10 yr
Control diagnosis) (intensive) f/u (macro benefit)
Middle age Reduced micro
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller mariawasfy. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for CA$15.22. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75632 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now