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UNE CHEM 1005 Unit 2 Review Questions With Complete Solutions
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  • CHEM 1005
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  • University Of New England (UNE )

Which oxidation reaction requires the coenzyme FAD because it involves oxidation of a carbon-carbon single bond to a double bond? correct answer: oxidation of succinate to fumarate Pyruvate dehydrogenase kinase will facilitate which of the following reactions? correct answer: The pyruvate dehy...

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  • July 27, 2023
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UNE CHEM 1005 Unit 2 Review Questions
With Complete Solutions
Which oxidation reaction requires the coenzyme FAD because it
involves oxidation of a carbon-carbon single bond to a double
bond? correct answer: oxidation of succinate to fumarate

Pyruvate dehydrogenase kinase will facilitate which of the
following reactions? correct answer: The pyruvate
dehydrogenase kinase will phosphorylate and inactivate the
pyruvate dehydrogenase complex.

Explanation: When the PDC is phosphorylated by pyruvate
dehydrogenase kinase, the PDC will become inactive.

A deficiency in thiamine (TPP) will directly decrease the
activity of which of the following enzymes? correct answer:
Transketolase

Within the red blood cell glucose can be oxidized to which of
the following products?

oxaloacetate and acetyl CoA
lactate and ribose 5-phosphate
lactate and acetyl CoA
ribose-5-phosphate and ATP correct answer: lactate and ribose
5-phosphate

,Explanation: Glucose is oxidized to lactate (as mitochondria are
lacking in the red blood cell) and ribose 5-P through the pentose
pathway

Which of the following enzymes is involved in the non-
oxidative portion of the Pentose Pathway?


Aldolase B
Glucose -6 phosphate dehydrogenase
Galactokinase
Transketolase correct answer: Transketolase

A deficiency in glucose 6-phosphate dehydrogenase reduces the
levels of NADPH in the red blood cell. This leads to an increase
in which of the following compounds with the cell?

Oxidized glutathione
Ribulose 5-phosphate
NADH
Fructose 6 -phosphate correct answer: Oxidized glutathione

Complex II (Succinate dehydrogenase) is not considered to be
part of the process of oxidative phosphorylation because it is
unable to do which of the following activities? correct answer:
Pump protons from the mitochondrial matrix to the
intermembrane space

Individuals with deficiency in glucose 6 phosphate
dehydrogenase often present with hemolytic anemia. This is

, primarily due to a deficiency in which of the following
metabolic products? correct answer: NADPH

Glucose is transported from the intestine to the gut epithelium
by which of the following processes? correct answer: secondary
active transport

Explanation: This process relies on a Na gradient to move
glucose from the intestine to the epithelium. Generation of the
sodium gradient requires ATP and therefore the movement of
glucose is a secondary active transport

Which of the following allosterically activates mammalian
isocitrate dehydrogenase? correct answer: ADP

All of the following stimulate the release of insulin except:
correct answer: epinephrine

Explanation: Epinephrine is a counter regulatory hormone that
facilitates catabolic reactions. See Table 26.2.

Which of the following is a key inhibitor of α-ketoglutarate
dehydrogenase? correct answer: NADH

Explanation: NADH is a key inhibitor of the activity of α
ketoglutarate dehydrogenase (see figure 20.12)

In the non-oxidative portion of the pathway 2-carbon fragments
of keto-sugars can be transfered to other sugars to generate a
larger sugar molecule. This reaction is catalyzed by which of the
following enzymes? correct answer: transketolase

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