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Summary 1. Greatest mind map of CELL INJURY "basic pathology"
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cell injurycellular responses
intracellular accumulation
cell aging
subcellular alteration
adaptation
causes
response factors
pathgenesis
chemical
immunologic
biologic
nutritional
physical
genetic
hypoxia
age
cell
stress
type and adaptability
type and severity
ATP depletion
genetic apparatus
membrane
5-10% decrease
results
causes
low glu
toxins
hypoxia
anaerobic glycolysis
pumps failure
Na+ Ca+2 ER swelling
mito swelling
cell swelling
intracellular fat
ribosomal detachment
activation
accumulation in mito phospholipases
proteases
endoucleases
ATPase
lactosis
disruption of organelles
loss basophilia
chromatin clumping = pyknosis
lysosomes mitosis growth regulating ptn&Enz structural ptn
causes
results
direct
ATP Ca++ FREE radical toxins
viral ptn C5-9
causes
mechanism
anti oxidant
ptn oxidation
thymine reaction
lipid peroxidation
membrane damage fragmentation & cross linking
DNA damage
cytoskeleton damage
atherosclerosis
ischemic reperfusion
hyperoxia
radiation
chemical toxicity
carcinogenesis
inflammation
aging cell
kill microbial agent
destruct tumor cell
vitamin
A,C,E
sulfhydryl
glutathione
cystien
serum ptn
ceruloplasmin
transferin
decrease
increase
irreversible
reversible
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