Exam (elaborations)
BCH210 Week 4 Questions With Complete Solutions
- Course
- BCH210
- Institution
- University Of Toronto (U Of T )
BCH210 Week 4 Questions With Complete Solutions
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BCH210 Week 4 Questions WithComplete Solutions
Properties of Catabolism correct answer: Breaking down larger
macromolecules, exergonic, oxidative. Creates high energy
molecules in teh process (ex. ATP, NADH, FADH2)
Properties of Anabolism correct answer: Building up
macromolecules from smaller molecules, reductive, endergonic.
Requires high energy molecules to fuel the reaction (ex. ATP,
NADH, FADH2).
Metabolism correct answer: The conversion of one molecule
into another. (Cassifications: phototrophs, chemotrophs,
autotrophs, heterotrophs; humans are chemiheterotrophs.)
How to regulate a pathway correct answer: Feedback inhibition
by product, gene level expression of enzymes, cofactor
restriction, allosteric modulation, concentration of substrate,
diverging pathways, inhibition of the enzyme.
Metabolon correct answer: A multi enzyme complex. When the
enzymes come together, they make more efficient use of
cofactors and substrate intermediates.
Enzyme regulation correct answer: Competitvely, Non-
competitively, allosterically, or 100% by covalent modifications.
, Amphibolic intermediates correct answer: An intermediate that
takes part in both catabolic and anabolic reactions. They link
metabolic pathways together. An example is Acetyl CoA (links
PDC, Krebs, etc).
What do we need enzyme-catalyzed reactions correct answer:
Speeds up the rxn (rate of equilibrium attainment), lowers the
activation energy, stabilize the transition state, produce
metabolites needed for cells, they don't undergo structural
changes (conformational not configurational), they can couple
favorable and unfavorable rxns together to produce an overall
favorable rxn.
Thermodynamic Equation correct answer: ΔG=ΔG°'+ RT ln
[P]/[S]
Standard free energy change correct answer: ΔG°' = -RT ln Keq
Keq and G correct answer: If Keq >1, G is -ve and the reaction
proceeds forward (exergonic-release of energy). If Keq <1, G is
+ve and the reaction proceeds in the reverse direction
(endergonic-absorbs energy). If Keq=0, G=0 and the reaction is
reversible.
Metabolic/Pathway flux correct answer: Metabolic flux is the
conversion of metabolites through a pathway by way of
enzymes. Metabolite concentrations and enzyme regulation can
determine a pathway's activity/directionality/flux.
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