Class notes
Class notes PNM
- Course
- PNM (PNM300)
Class notes for pharmacology week 2 for practical nursing students
[Show more]
Seller
Follow
Content preview
WEEK 2: PHARMA Prof:Drug Therapy Across Lifespan Basic Considerations (Pediatric) and (Adults)
Peds vital organs are immature - metabolism is different than adult
Neonate = birth and 1 month
Infant = 1 and 12 months
Child = 1 and 12 years
Absorption
● 1-2yrs less acidic ph
● F-p elimination is reduced d/t liver immaturity
● reduced bile salt - decreased bioavailability
● IM absorption is faster and irregular - causing a risk for dehydration
● Immature bbb?? More sedating effect as more drug enters the brain
What are the factors Affecting Ped Dosage
● Skin is thin and permeable
● Stomach lacks acid to kill bacteria
● Lungs have weaker mucus barriers
● Body temp are less well regulated, and dehydration is occurs easily
● Liver and kidneys are immature, impairing drug metabolism and excretion
Strategies to decrease Polypharmacy?
● Communication/ or have a GP
● 1 Pharmacy = customized blister packs
Drug Therapy in Pregnant
What occurs during FIRST TRIMESTER?
● (1) fetus development (2) organ changed
Why is the FIRST TRIMESTER generally the greatest dangerous stage for pregnancy?
● Because of drug-induced development defects
Drugs cross the placenta primarily by?
● Diffusion
What are the factors that affect safety during pregnancy?
● Drug properties
● fetal gestational age
● Maternal factors - any changes in mother's physiology = can affect the amount of drug to which the fetus
may be exposed
Why is in the Last Trimester, drug transfer more likely to occur?
● Enhance blood flow to the fetus
● Increased fetal surface
● An increased amount of free drug in the mother’s circulation
Define the Pregnancy Safety Consideration
What is category A?
● No harm to the human fetus
What is category B?
● No risk to animals, info invalid in human
What is category C?
● Adverse effects reported in animals, not avail info in humans, but potential benefits may warrant the use of
drugs by pregnant women
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller willowsunsent. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for CA$11.60. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75632 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now