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Summary of the entire course Preclinical Drug Research (18/20) CA$22.02   Add to cart
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Summary

Summary of the entire course Preclinical Drug Research (18/20)
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  • Course
  • Preclinical Drug Research
  • Institution
  • Universiteit Antwerpen (UA)

Summary of the entire course Preclinical Drug Research (18/20): This is a compact summary of the whole course from the subject Preclinical Drug Research (slides, lectures, and all the important information from the insert) & elaboration of all the old exam questions from the course Preclinical Drug...

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Document information

  • October 13, 2023
  • 14
  • 2023/2024
  • Summary

Subjects

  • preclinical
  • preclinical drug research
  • pharmacokinetics
  • delputte
  • biopharmaceuticals
  • vaccines
  • antibodies
  • biotechnology
  • biotechnological products
  • biomedical sciences

Written for

  • Universiteit Antwerpen (UA)
  • Biomedische Wetenschappen
  • Preclinical Drug Research
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Summary of Preclinical Drug
Research: Partim Delputte

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Biopharmaceuticals: prof. Delputte
WHAT ARE BIOPHARMACEUTICALS?
For example EPO, insulin, vaccines, mAb,…

1. Protein-like structures
2. Oligonucleotides
3. Sugars / glycans
a. Usually not used: too complex & usually low
affinity to targets: side effects
4. Cell-typing
a. Isolate cells from patients, treat them and inject them again

Biopharmaceuticals are VALUABLE. You can have novel innovative therapies for significant unmet
medical needs. It is a radically new approach. 1/3 – ½ of all drugs in development are
biopharmaceuticals.

- NME = new molecular entity = when a small molecule goes into development
- NBE = new biological entity

Advantages !!!
 Inherently highly specific for the target
 Minimum risk for non-mechanism based toxicity and safety
 Capable of increasing growth factors, hormones, enzymes…
 Can modulate protein/protein interactions that cannot be targeted by small molecules
 Applicability in multiple therapeutic areas and for multiple targets
 Value
o Larger profits for companies
o Therapeutic value

Definition
Small molecules are usually taken orally, while biopharmaceuticals are mostly administered IV.

The term biopharmeuticals is widely used, but is hardly ever defined by its users, definitions of
biopharmaceuticals in common use vary greatly.

- Pharmaceutical: involves chemical (non-biological) medicinal products manufactured using
chemical sources and processes.
- Biopharmaceutical: involves inherently biological products with manufacture involving
biological sources and processes

= Everything that living organisms can make: proteins, nucleic acids, glycans, viruses, bacteria,
vaccines, cell-based therapies…

Problem of antisera / antibodies = we make antibodies against the antibodies of the horse.
Antivenom usually only works once. Also biologicals are unstable and difficult to store.




Gedownload door: InnePatteet | inne.patteet@hotmail.be
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