Exam (elaborations)
6343 - Multiple Sclerosis Questions And Answers With Complete Solutions
- Course
- MULTIPLE SCLEROSIS
- Institution
- Concordia University ( )
6343 - Multiple Sclerosis Questions And Answers With Complete Solutions
[Show more]
Content preview
6343 - Multiple Sclerosis Questions AndAnswers With Complete Solutions
Give a brief key-point summary of multiple sclerosis. correct
answer: It is a progressive disease of the central nervous
system. Essentially, genetic and environmental factors interact
to form a disease in which T cells pass through the blood brain
barrier and attack the myelin found on CNS axons which
interrupts nerve cell transmission, and ultimately leads to the
death of the underlying axon. This results in a wide range of
motor, sensory, and cognitive impairments. Inflammation from
this process creates plaques, a hallmark sign to diagnose this
disease. Symptoms can be treated and controlled, but never
cured. The patient will acquire disabilities, and while they may
live a reasonable life span, prognosis is ultimately fatal.
What are the cells targeted for destruction by multiple sclerosis?
correct answer: Oligodendrocytes, the myelinating cells of the
CNS.
(Schwann cells are the myelinating cells of the PNS)
(Also, oligodendrocytes are different than schwann cells in that
they provide myelination coverage to multiple axons
simulatenously. So the destruction of a single oligodendrocytes
can disrupt transmission at multiple synaptic pathways at once.)
What does the inflammation response in the brain cause in MS
victims? correct answer: Immune and hormone dysregulation,
independent of the debilitating effects of demyelination.
, It is also responsible for the hallmark plaque/lesions sites that
can be seen in imaging.
What is gliosis? correct answer: Literal translation "condition of
glue", but more relevantly, it is the fibrous scarring condition
that replaces myelin in progressive MS.
What is the role of neuronal mitochondria in multiple sclerosis?
correct answer: Inflammatory products from the autoimmune
attacks of T cells that get past the BBB into the CNS degrade
mitochondrial DNA, leading to an energy failure in axonal
transmission once enough aberrant mitochondria are present.
Is the white matter or gray matter affected by MS? correct
answer: BOTH!
First the (white matter) myelination is destroyed. Then without
its protection, the axon (gray matter) dies.
From a bigger picture, it will affect both cognition and
processing (gray matter function) and synaptic transmission
(white matter function)
What is the geographic risk factor for MS?
What is the genetic risk factor for MS?
What are the environmental risk factors for MS?
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Classroom. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for CA$15.98. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
78291 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now