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UNE Medical Biochemistry Midterm Exam – Qs & As
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UNE Medical Biochemistry Midterm Exam – Qs & As
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UNE Medical Biochemistry Midterm Exam – Qs & AsWhich of the following proteins is likely to have quaternary structure?
Correct Ans - A multimeric protein that contains multiple peptide
chains
Prosthetic groups are complex nonprotein molecules that participate in
catalysis by providing functional groups that form a covalent intermediate
between the enzyme and the substrate. Which of the following is an
example of a coenzyme or cofactor that participates in a covalent catalysis
reaction? Correct Ans - Pyridoxal phosphate
Which of the following best describes a protein domain? Correct Ans -
A section of a protein structure sufficient to perform a particular chemical
or physical task
Cleavage of fructose 1,6 bisphosphate to dihydroxyacetone and
Glyceraldehyde 3-phosphate involves the breaking of a carbon-carbon bond
through a process other than oxidation or hydrolysis. This is achieved by
what class of enzymes? Correct Ans - Lyase
A 55-year old man is brought to the emergency room with a chief
complaint of chest pain and tingling in his left arm. Elevation of which of
the following enzymes in circulation would be most indicative of
myocardial infarction? Correct Ans - Troponin
Allosteric activators of hemoglobin will increase substrate binding through
which of the following mechanisms? Correct Ans - Binding the
protein, and keeping it in the "R" conformation
Which of the following best describes tertiary structure? Correct Ans -
Interactions between alpha helices and beta sheets to form a domain
How do most enzymes reduce the activation energy needed to move a
reaction forward? Correct Ans - providing an active site most
complementary to the transition state
Domains are common structural elements that retain a particular function
within the protein. Which of the following is an example of a protein
, domain? Correct Ans - An arrangement of beta-strands connected
by alpha-helices (beta-alpha-beta-alpha)
Which amino acid would not be commonly found in the middle of an alpha-
helical domain? Correct Ans - Proline
Which of the following is a true statement with regards to the malate-
aspartate shuttle system? Correct Ans - Generates 2.5 molecules of
ATP in mitochondria per each NADH from glycolysis.
Complex II (Succinate Q-reductase) is not considered part of the process of
oxidative phosphorylation because it is unable to do which of the following
activities? Correct Ans - Pump protons from the mitochondrial
matrix into the inter membrane space.
Succinate is a substrate for which complex in the electron transport chain?
Correct Ans - Complex II (Succinate-Q reductase)
The glycerophosphate shuttle is the major shuttle of most tissues. Which of
the following best describes the transfer of electrons by this shuttle?
Correct Ans - Electrons are directly transferred from glycerol 3-
phosphate to an FAD containing glycerol phosphate dehydrogenase.
A 19-year old male is being evaluated for muscle weakness. Evaluation of a
muscle biopsy revealed normal rates of succinate oxidation but very low
rates of pyruvate oxidation. Further testing determined normal levels of
enzymatic activity in both malate dehydrogenase and pyruvate
dehydrogenase. Based on this data, the patient may have a mutation in a
gene encoding for which mitochondrial protein? Correct Ans -
Complex I (NADH Q-oxidoreductase)
Which of the following components of the electron transport chain passes
electrons to O2 causing it to be reduced to H2O? Correct Ans -
Cytochrome c oxidase
As electrons flow through complexes in the inner mitochondrial membrane,
protons are pumped from the matrix into the inter membrane space. Which
of the following statements is most reflective of the pH in the inter
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