Class notes

PH and PKa - Biochemistry

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Course
MBB 222 (MBB222)

Institution
Simon Fraser University (SFU )

Condensed class notes summarizing lectures about pH and pKa relating to biochemistry. Includes pH, pKa, Henderson-Hasselbach equation, buffer zone, and titration curves. Contains illustrations and diagrams.

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Uploaded on January 18, 2024
Number of pages 2
Written in 2023/2024
Type Class notes
Professor(s) Dustin king
Contains 5-7

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PH & PKa

of dissociation
Key forey Rin AtBX+d the
equilibrom constant,
key
degree
the

givesEquilibrium
, ,
.

keg [productseq]
=
=
[Cg[Deg] in Defines THE compostion As WHEN CONCENTRATIONS Are

[REACTANSegJ
[teg] [Beg]
-To
longer changing
Kn-water ionreatron Constant

kn =
[H20] (key =
[N]CH JSOH] +
= [H J [OH-]
+
Note : As
Equilibrium , The concentration of IzO is

[O] 55 .
5M
↑ 25°, Kwis 1 0
. x 10-14 M3
-

Ka-The Acid dissociation of Weak Acids How Acid Holds Weaker Acids Hold
Tightly procou
Constant .
Measures an on To Ms .

ka [H ] [A-]
+

keg and are less dissociate Ka-
Ther
protons Likely Thus
They have a
=
=
Onto to . ,
small

[HA] Acids : Ifor reference hats a work foid and
WEAK SMALL Ka debase
longingCOMPLETE
res

Aoids: Ka Acids
Strong Bog
vost : Almost

strang
WILL
>

PKa-THE inverse of The Ka describe of Acids
- Fontte/Dissociate

THE DO not Hold
Aqueous
in

Their
solutions

PROTO
log STRENGTH
, used To THE 5 ,
On To

PKa
-log(ka) Log WEAK Acids:Small Ka,
BigPKa
Pla
Try strongly
INSTEAD,
They Tend to Don
=
or .

Ka
Bug
Acros : SMALL

Strong
,

PH -Expresses The Concentration of t
solution . Ph and PKa Are RELATED via The Henderson-Hasselbach :
aqueous
Ions in an
Equ
PH +
+

-Log[H ]
=

LogCity
or

PKatLog The
hererson-Hasselbach
PH =

for PHAPK
PH is A Lo ArMAMic SCALE Each
Equation
g
, a

Higher
increase 10-fold They The inverse Tha THE CHT]
log
is a increase in :
makes r So is, The Lower The

PHA

HigHCH
Vice VERSA +
.

] -
>
Low PH
-
Low [H -
+
Phys ICAL PH :
High
PH
rozog
>
&
234567891011 12 13 14

Acidic Basic/ALKALINE
-
6-
5
↓
HAs A PH of 2 THE
Example : LEMON
joice <6 5 NEUTRAL 7 54

↳
. . .

6 5-7 5
.
.

CONCENTRATion of [Htj is 1
.
0x103 M

Buffers find CHt] and [AS
BufferingRange-the
& TiTratton curve Below Can Be used to THE Ph WHERE are

This is THE PKa HOWEVER PKaEI This is due BuffERS Acid BASE RESIST
Equal Changes
A WEAK tiTS
Conjugate
.
. THERES An Allowance : .
TO
,

Buffers Are Essential from
Brozog
TOCH] & [A-]
Biolog Damag
in THE PROTECT ICAL Molecules

Range
WITHIN A CERTAIN .

.
7
Due Pt
L Histidine And Buffers
changes
Extreme in Appare oud As
They
To

g
.

CAN Exist As PROTONATEd or DEPROTONATED Al Physio iCAL PH
9

Bonging
Acidosis Blood Acidic Blood plasma Buffered
: is 700
>
-
-
is
By
ALKALOSIS : Blood S Too Basic THE BICARBONATE SYSTEM
# HCO3HeCOzT HOt C
*

PROTON
Production of HyCO3
PROTON
CAN BE Acceptor DONOR

of
By
RegulatingExchange COzig) (Bresting
MANPUAED

Acidosis - increase of CO2 , Body [CO2]
Lowering
Exalation in THE .

ALKALOSIs- Slow [202]
Breathing
Rate TO increase
I

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