Class notes

PH and PKa - Biochemistry

3 views 0 purchase

Course
MBB 222 (MBB222)

Institution
Simon Fraser University (SFU )

Condensed class notes summarizing lectures about pH and pKa relating to biochemistry. Includes pH, pKa, Henderson-Hasselbach equation, buffer zone, and titration curves. Contains illustrations and diagrams.

[Show more]

Preview 1 out of 2 pages

View example

Uploaded on January 18, 2024
Number of pages 2
Written in 2023/2024
Type Class notes
Professor(s) Dustin king
Contains 5-7

CA$4.16

Added

Add to cart Add to wishlist

100% satisfaction guarantee
Immediately available after payment
Both online and in PDF
No strings attached

PH & PKa

of dissociation
Key forey Rin AtBX+d the
equilibrom constant,
key
degree
the

givesEquilibrium
, ,
.

keg [productseq]
=
=
[Cg[Deg] in Defines THE compostion As WHEN CONCENTRATIONS Are

[REACTANSegJ
[teg] [Beg]
-To
longer changing
Kn-water ionreatron Constant

kn =
[H20] (key =
[N]CH JSOH] +
= [H J [OH-]
+
Note : As
Equilibrium , The concentration of IzO is

[O] 55 .
5M
↑ 25°, Kwis 1 0
. x 10-14 M3
-

Ka-The Acid dissociation of Weak Acids How Acid Holds Weaker Acids Hold
Tightly procou
Constant .
Measures an on To Ms .

ka [H ] [A-]
+

keg and are less dissociate Ka-
Ther
protons Likely Thus
They have a
=
=
Onto to . ,
small

[HA] Acids : Ifor reference hats a work foid and
WEAK SMALL Ka debase
longingCOMPLETE
res

Aoids: Ka Acids
Strong Bog
vost : Almost

strang
WILL
>

PKa-THE inverse of The Ka describe of Acids
- Fontte/Dissociate

THE DO not Hold
Aqueous
in

Their
solutions

PROTO
log STRENGTH
, used To THE 5 ,
On To

PKa
-log(ka) Log WEAK Acids:Small Ka,
BigPKa
Pla
Try strongly
INSTEAD,
They Tend to Don
=
or .

Ka
Bug
Acros : SMALL

Strong
,

PH -Expresses The Concentration of t
solution . Ph and PKa Are RELATED via The Henderson-Hasselbach :
aqueous
Ions in an
Equ
PH +
+

-Log[H ]
=

LogCity
or

PKatLog The
hererson-Hasselbach
PH =

for PHAPK
PH is A Lo ArMAMic SCALE Each
Equation
g
, a

Higher
increase 10-fold They The inverse Tha THE CHT]
log
is a increase in :
makes r So is, The Lower The

PHA

HigHCH
Vice VERSA +
.

] -
>
Low PH
-
Low [H -
+
Phys ICAL PH :
High
PH
rozog
>
&
234567891011 12 13 14

Acidic Basic/ALKALINE
-
6-
5
↓
HAs A PH of 2 THE
Example : LEMON
joice <6 5 NEUTRAL 7 54

↳
. . .

6 5-7 5
.
.

CONCENTRATion of [Htj is 1
.
0x103 M

Buffers find CHt] and [AS
BufferingRange-the
& TiTratton curve Below Can Be used to THE Ph WHERE are

This is THE PKa HOWEVER PKaEI This is due BuffERS Acid BASE RESIST
Equal Changes
A WEAK tiTS
Conjugate
.
. THERES An Allowance : .
TO
,

Buffers Are Essential from
Brozog
TOCH] & [A-]
Biolog Damag
in THE PROTECT ICAL Molecules

Range
WITHIN A CERTAIN .

.
7
Due Pt
L Histidine And Buffers
changes
Extreme in Appare oud As
They
To

g
.

CAN Exist As PROTONATEd or DEPROTONATED Al Physio iCAL PH
9

Bonging
Acidosis Blood Acidic Blood plasma Buffered
: is 700
>
-
-
is
By
ALKALOSIS : Blood S Too Basic THE BICARBONATE SYSTEM
# HCO3HeCOzT HOt C
*

PROTON
Production of HyCO3
PROTON
CAN BE Acceptor DONOR

of
By
RegulatingExchange COzig) (Bresting
MANPUAED

Acidosis - increase of CO2 , Body [CO2]
Lowering
Exalation in THE .

ALKALOSIs- Slow [202]
Breathing
Rate TO increase
I

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller kac26. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for CA$4.16. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

76449 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling