Pharmacology Quiz 5 Practice - NSAIDs and Opioids 2023/2024 passed

Pharmacology Quiz 5 Practice - NSAIDs and Opioids What does NSAID stand for? - correct answer Non-Steroidal Anti-Inflammatory Drug What are prostaglandins? - correct answer Local (paracrine) mediators of inflammation (short half-life) How are prostaglandins synthesized? - correct answer Synthesized by cyclooxygenase enzyme from arachidonic acid, makes thromboxane also (platelet aggregation) What do prostaglandins cause? - correct answer ~Increased sensitivity of pain receptors ~Increased body temperature (fever) ~Secretion of cytoprotective mucus in stomach (good) ~Uterine wall contractions ~Renal vasodilation What is an effect of prostaglandins that we may want? - correct answer Secretion of cytoprotective mucus in stomach What are cyclooxygenases? - correct answer Enzymes that control prostaglandin production What are the two isozymes of cyclooxygenase (COX)? What do they cause? - correct answer 1. COX1 - mainly affects stomach mucus production 2. COX2 - pain sensitivity, fever, inflammation How do NSAIDs work? - correct answer Inhibiting cyclooxygenases What are NSAIDs used for? - correct answer ~Baby aspirin to reduce risk of MIs and strokes