Summary

Hypercoagulation Disorders Summary Notes

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Course
Usmle

Institution
Usmle

Simplified approach to hyper coagulation disorders including: Protein C or S deficiency, Factor V Leiden, Antiphospholipid antibody syndrome. Includes fantastic graphic of the coagulation cascade for reference.

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Uploaded on February 1, 2024
Number of pages 7
Written in 2022/2023
Type Summary

heme
hematology
hypercoagulation
coagulation cascade
medicine
medical school
sumary notes
blood
blood disorders
internal medicine
summary

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DVT probability
(Wells’ score)

Likely Unlikely

Compression Hypercoagulation Disorders
US D-dimer

- + - +

Compression
D-dimer Treat No DVT US
Venous Thromboembolism (VTE)
Stasis
Post-thrombotic syndrome:
• Development of chronic venous stasis signs/symptoms 2/2 DVT
• Thrombus formation à inflammatory response in superficial or deep vein • Pain, venous dilation, edema, pigmentation, venous ulcers
• Superficial thrombophlebitis • Villalta score: clinical severity
• Deep vein thrombosis (DVT) • Tx: elevation, exercise, compression stockings, intermittent pneumatic
• Pulmonary embolism (PE) compression therapy, skin/wound care

Pathophysiology: Endothelial Ddx elevated D-dimer:
- + - + 1. Endothelial damage à induces hemostasis
2. Venous stasis à inhibits clearance and dilution of coag factors
Hypercoagulability injury • Arterial thromboembolic dz (MI, CVA, Afib)
• Venous thromboembolic disease (DVT, PE)
• DIC
3. Hypercoagulability = more likely to thrombose • Preeclampsia and eclampsia
• Increases with age, surgery, trauma, neoplasm, blood dyscrasias, prolonged immobilization, hormones (E), APS, heart failure • Abnormal fibrinolysis, use of thrombolytic agents
• CVD, CHF
DVT • Severe infection/sepsis/inflamm
Clinical presentation: • Surgery/trauma

Serial US • Unilateral leg edema, erythema, warmth, tenderness, palpable cord (thrombosed vein) • SIRS

No DVT (5-7 d) No DVT Treat • Phlegmasia alba dolens (white appearance), phlegmasia cerula dolens (acute pain and edema) with massive thrombosis
• Sickle cell vasoocclusive episode
• Severe liver dz
• Homan’s sign (pain with dorsiflexion) (unreliable) • Malignancy
Ddx: muscles strain/tear, lymphangitis/lymph obstruction, venous valve insufficiency, ruptured popliteal cyst, cellulitis, arterial occlusive dz • Renal disease
• Normal pregnancy
• Venous malformation
INVESTIGATIONS
• D-dimer Test Principle Readout Pros/Cons
• Doppler US* D-dimer breakdown product of fibrin positive/negative sensitive but not specific; cannot be used alone
- + • MRI
Compression detects “non-compression” of a positive/negative sensitive for proximal; one negative does not rule out
• Impendence plethysmography ultrasound venous segment DVT
• Venography
• CTPA, V/Q scan if PE suspected V/Q scan looks for ventilation/perfusion normal/low/intermediate/high probability preferred in younger pts with normal CXR
mismatch in lungs *normal excludes PE more “non-diagnostic” results
CTPA rapid CT with thin slices, bolus of negative/positive/technically inadequate preferred in individuals with a positive D-dimer
dye and radiation *negative can rule out a PE more results of unknown clinical significance
No DVT Treat contraindicated if renal issues
may catch more clots that aren’t clinically relevant

, Coagulation Cascade

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