Neo/Peds Questions with complete solution

Vascular smooth muscle is largely dependent on which of the following intracellular ions?` - ANSWER-Ca2+ Which of the following substances prevents the release of Ca2+ from the sarcoplasmic reticulum? - ANSWER-cGMP-dependent kinase What is the primary physiologic activity of inhaled nitric oxide? - ANSWER-pulmonary vasodilation Which of the following medications contributes to an increased right-to-left intrapulmonary shunting? - ANSWER-Prostacyclin The respiratory therapist has initiated iNO at 20 ppm for an infant with pulmonary hypertension. After 2 hours a blood gas test reveals a 10% improvement in SaO2. What should the therapist do? - ANSWER-Keep iNO at 20 ppm and wait at least 2 hours before considering any change. The respiratory therapist has initiated nitric oxide for an infant with severe refractory hypoxemia. The initial dose was 20 ppm and titrated up to 30 ppm for the last 4 hours due to lack of response. However, there still is no response. What should the therapist do? - ANSWER-Discontinue iNO and consider a different therapeutic intervention Inhaled NO has been administered to an infant for nearly 4 hours. The respiratory therapist notices suboptimal response and suggests HFOV. What is the principle behind the potential benefit of adding this ventilatory modality to this infant? - ANSWER