100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
ILE VII Misc Antimicrobials Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution CA$11.51   Add to cart
Quickly navigate to
Preview
  2.  
  3. All Summer Modules Studies 2024
  4.  
  5. All Summer Modules Studies 2024
  6.  
  7. All summer modules studies 2024

Exam (elaborations)

ILE VII Misc Antimicrobials Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution

1 review
 6 views  0 purchase
  • Course
  • All summer modules studies 2024
  • Institution
  • All Summer Modules Studies 2024

ILE VII Misc Antimicrobials Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution

Preview 2 out of 6  pages

Document information

  • June 19, 2024
  • 6
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers

Subjects

  • ile vii misc antimicrobials questions with 100 a

Written for

  • All summer modules studies 2024
  • all summer modules studies 2024
  • All summer modules studies 2024
All documents for this subject (274)

1  review

review-writer-avatar

By: EXAMQA • 5 months ago

Seller

avatar-seller
Hkane

Reviews received

Content preview

ILE VII: Misc Antimicrobials
What are the two portions of vancomycin and the glyco/lipopeptides?
Glyco dissacharide and cyclic peptide
Which portion of vancomycin and the glyco/lipopeptides contains amino acids of
abnormal structure that cause a reaction in the body?
Cyclic peptide
Where and how does vancomycin bind?
Peptidoglycan via 5 hydrogen bonds
What does vancomycin cover?
MRSA, MSSA, Staph, Strep including PRSP, Bacillis, Listeria, and C. diff
ONLY GP because it is too big to get across the outer membrane of GN
Vancomycin is ___________ dependent and __________.
Time; bactericidal
What is resistant to vancomycin and why?
Enterococci; forms VanA which substitutes lactase (contains an O where the H
should be) where an ala should be in the D-ala-D-ala sequence making impossible
to bind (modified peptidoglycan)
When is vancomycin first line?
MRSA, staph epidermis, strep. pnumoniae, bacillis
- Serious infections caused by GP, beta-lactam resistant bugs
When should we measure troughs to make sure vancomycin is above the MIC?
30-60 minutes before the 4th or 5th dose
How is vancomycin excreted?
Renally; excreted unchanged in urine primarily through GF (not metabolized)
When is oral vancomycin used?
Only for local GI infection; does not absorb systemically
Vancomycin CNS penetration
Fair to poor; large and polar molecule
Vancomycin ADRs
Red man syndrome, phlebitis, nephrotoxicity
Can see some ototoxicity, but rare
Vancomycin Drug Interactions
Non-depolarizing muscle relaxants
AMINOGLYCOSIDES
Cholestyramine- will bind up drug and prevent it from working
What makes the vancins structurally different from vancomycin?
Additional amino sugars on the lipophilic side chain
Vancins MOA
Inhibit cell wall synthesis by binding to peptidoglycan and preventing cell wall
synthesis AND disruption of the cell membrane
How is vancin's MOA different from Vancomycin?
Lipophilic tails anchor the drug in bacterial cytoplasmic membranes to disrupt not
only structure, but function

, What will vancins kill?
MRSA, MSSA, VRSA, VISA, VSE, ENTEROCOCCI
Think of it as an extended spectrum vancomycin
Vancins are effective at _______ MICs compared to Vancomycin
Lower
Which vancin is effective against VRE?
Oritavancin
Which of the following drugs have a half life of about 8 hours?
Vancomycin, Oritavancin, Telavancin, Dalbavancin
Vancomycin, Telavancin
Which of the following drugs have a half life of more than a week?
Vancomycin, Oritavancin, Telavancin, Dalbavancin
Oritavancin, Dalbavancin
Vancins have a ____________ risk of ADRs compared to Vancomycin.
Lesser
Daptomycin MOA
Inserts itself into the cell membrane where it alters the structure of the membrane
creating holes that leak ions. This causes rapid depolarization and eventually cell
death.
Daptomycin is ___________ dependent
Concentration
Daptomycin Spectrum of Activity
Vancomycin resistant enterococci, MRSA, MSSA, VRE
What is active against VRE
Daptomycin and Oritovancin
What is unique about daptomycin?
It is deactivated by lung surfactant, so it should not be used to treat pneumonia
How is daptomycin eliminated?
Renally with very little metabolism
Daptomycin CNS Distribution
Bad
Daptomycin ADRs
Diarrhea, headache, dose dependent CPK elevations (watch with statins)
Daptomycin Drug Interactions
Not a CYP inhibitor or inducer
HOLD STATINS
Name the aminoglycosides.
Tobramycin, Gentamicin, Amikacin
Aminoglycosides MOA
Bind to 30S ribosomal subunit and cause mRNA codon to be misread; interfere with
the initiation complex of 30S and 50S with mRNA
Aminolgycosides will only kill ___________ bacteria.
Aerobic
What are the 3 ways aminoglycosides disrupt biosynthesis?

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller Hkane. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for CA$11.51. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

67474 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
CA$11.51
  • (1)
  Add to cart