Summary

Summary Hematopoiesis - Single Chapter

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Course
Medical Laboratory Science

Institution
Medical Laboratory Science

This chapter contains notes on the process of hematopoiesis (blood cell production). Topics include but are not limited to definitions relevant to hematopoiesis, basic cell morphology, individual cell proliferation production processes, and more. For more in-depth explorations of these topics, ...

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Uploaded on June 22, 2024
Number of pages 13
Written in 2023/2024
Type Summary

hematology
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bone marrow
hematopoiesis
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HEMATOPOIESIS

GENERAL BLOOD MORPHOLOGY

 55% plasma
o 91.5% water
o 8.5% solutes
 Albumin (55%)
 Globulins (38%)
 Fibrinogen (7%)
 Miscellaneous (electrolytes, non-protein nitrogen
compounds like urea, uric acid etc.)
 45% formed elements
o 44% RBC
o 1% WBC and PLT

BLOOD CELL MORPHOLOGY

ERYTHROCYTES (RED BLOOD CELLS)
 Read where they don’t overlap (unless WBC count is <2)
 Consists of plasma membrane that surrounds Hgb and electrolytes
 Biconcave disc ~7-8um in size
 90fL volume
 Central portion of the cell creates an area of central pallor
o Fairly uniform in shape and size
o No nucleus or inclusions
 Mature RBCs
o Not able to synthesize hemoglobin
o Anucleated (lack nucleus)
o No mitochondria or ribosomes
o Pliable, flexible, and deformable

PLT
 1-4um
 Vary in shape
 Reddish-purple granules in small amounts fi bluish cytoplasm
 Average of 7-15 PLTs per oil immersion field
 Estimate the number in 10 fields when reading
 PLTs contain molecules needed for hemostasis

, LEUKOCYTES
Granulocytes:
 Multinucleated
 Lobed nuclei
 Three types:
o Neutrophil
o Eosinophils
o Basophils
Monocytes:
 One nucleus
 Lobed nuclei
Lymphocytes:
 One nucleus
 Non-lobed nuclei

Immature cells of any type are abnormal. All cells play a role in immune
function.

NEUTROPHILS 50-70%
Segmented:
 3-4 lobes
o Hyper-segmented:
abnormally high number of
lobes in a neutrophil
 Chromatin is heavily clumped,
coarse or pyknotic
 Cytoplasm is light pink,
secondary granules pink-neutral
 Twice the size of RBC
 Segmentation allows nucleus to
pass through opening and focus on selected prey
 Secondary granules contain alk
phos

Bands: (2-6%)

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