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ONS Chemotherapy Course questions and answers
ONS Chemotherapy Course questions and answers
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ONS Chemotherapy Course5-fluorouracil - correct answer-Antimetabolite
**leucovorin given concurrently
**take year round photosensitivity precautions
**cardiotoxicity
**Bolus can cause increased mucositis so have patient suck on ice chips for 10-15 min pre
and post. Can also cause hyperpigmentation at peripheral site
**Continuous can cause N/V/D and photosensitivity
adjuvant therapy - correct answer-used after the primary treatments have been completed to
decrease the chance that a cancer will recur
Agranulocytes - correct answer-T lymphocytes, B Lymphocytes, and Monocytes
Alkylating Agents - correct answer-synthetic chemicals containing alkyl groups that attack
DNA, causing strand breaks
Side Effects:
-secondary malignancies
-hypersensitivity reactions
-GI toxicities (N/V/D)
-highly emetogenic
-Renal Toxicity (need BUN and Creatinine prior)
Anthrayclines - correct answer-interfere with enzymes necessary for DNA to replicate
**work in all phases of the cell cycle
**Lifetime dose limits to prevent permanent cardiotoxicity and pulmonary fibrosis
**Daunorubicin, Doxorubicin, Epirubicin, Idarubicin
Antimetabolites - correct answer-function by blocking DNA and RNA growth
*work in the S phase therefore very effective in fast growing tumors
**Vidaza, Xeloda, 5 FU, Cytarabine, Dacogen, Methotrexate
**can cause photosensitivity, GI toxicities, and Hand Foot and Mouth
, **vigorous hydration especially with high tumor burden to prevent TLS
Azacitidine (Vidaza) - correct answer-Antimetabolite
**IV or SC
**IV can cause hypokalemia, weakness, rigors and petechiae.
Bleomycin - correct answer-Nonanthracycline;antitumor antibiotics
**lifetime dose of 400 units for pulmonary fibrosis
**those with lymphoma have a greater risk of anaphylaxis (2 test doses are often done)
**watch for SOB, hyperpigmentation of skin, nail changes, erythema
**protect skin from exposure
**risk for pulmonary toxicity if given oxygen during procedures
Capecitabine (Xeloda) - correct answer-Antimetabolite
**oral 5 FU
**take within 30 minutes of meal with water
**associated with Hand Foot Mouth
**can increase INR with Coumadin
**can increase bilirubin
Carboplatin (Paraplatin) - correct answer-alkylating agent-platinum based
**Hypersensitivity reaction
**harder for those >65
**harder on kidney function
**cause neurotoxicity
**Can cause hearing loss
**first 24 hours nausea
Cell Mediated Immunity - correct answer-Type of immunity produced by T cells that attack
infected or abnormal body cells.
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