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Thiopental - Pharmacokinetics all questions solved 100 accurately latest version
Thiopental - Pharmacokinetics all questions solved 100 accurately latest version
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Thiopental - PharmacokineticsAcidosis -✅✅-Increases the unionized fraction of thiopental
Acute Intermittent Porphyria - ✅✅-Causes severe abdominal pain, labile
hypertension, diaphoresis, arterial vasospasm, bulbar paralysis, cerebellar
dysfunction, and paralysis of respiratory muscles
Alkalosis -✅✅-Increases the ionized fraction of thiopental
Antianalgesic effects - ✅✅-Pain threshold lowered by thiopental
Barbiturates - ✅✅-Stimulate increased hepatic microsomal protein content
Beta-blocker therapy - ✅✅-Impairs compensatory HR response and
accentuates BP decrease
Biotransformation - ✅✅-Metabolism of thiopental
Blood-brain barrier - ✅✅-Only unbound, protonated, unionized thiopental
crosses
Cardiac dysrhythmias - ✅✅-Unlikely in the presence of adequate ventilation
and oxygenation
Cerebral blood flow -✅✅-Decreased by thiopental
Cerebral perfusion pressure - ✅✅-Increased as the drop in intracranial
pressure exceeds the drop in intracranial blood flow
Cerebral vasculature - ✅✅-Constricted by thiopental
CMRO2 - ✅✅-Decreased up to 50% in the presence of isoelectric EEG
Contraindications - ✅✅-Absolute: Acute intermittent or variegate Porphyria,
Status asthmaticus, Hypersensitivity. Relative: Severe cardiovascular disease,
Hypotension, History of reactive airway disease
Coronary blood flow - ✅✅-Increased by thiopental
, CYP 450 system enzymes - ✅✅-CYP3A4, CYP3A5, CYP3A7 metabolize
thiopental
Decreased incidence - ✅✅-Use of lower concentration thiopental and
methohexital
Depression of medullary and pontine ventilatory centers - ✅✅-Results in
decreased ventilatory response to hypercapnea and hypoxia
Distribution - ✅✅-Determined by lipid solubility, protein binding, and degree
of ionization
Dose-dependent decrease in contractility - ✅✅-Results in decreased stroke
volume and cardiac output
Drug interactions - ✅✅-Increased CNS depression with alcohol, CNS
depressants, antihistamines, isoniazid, methylphenidate, MAO inhibitors,
chloramphenicol
EEG changes - ✅✅-Increased amplitude and decreased frequency with
thiopental
✅✅-Excretion of thiopental occurs within the kidneys
Elimination -
Enzyme inducers - ✅✅-Increase metabolism of oral anticoagulants, oral
contraceptives, digoxin, phenytoin, tricyclic antidepressants, corticosteroids,
bile salts, and vitamin K
Enzyme induction - ✅✅ -Of CYP3A4, CYP3A5, & CYP3A7 after continuous
administration of barbiturates
Excitement and disorientation - ✅✅-May be induced by small doses of
thiopental
Extravasation - ✅✅-Causes tissue irritation and sloughing
Geriatric and premedicated patients - ✅✅-Require smaller dosages of
thiopental
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