Exam (elaborations)
PCOL 838A Exam Questions_ Neoplasia (1).
- Course
- Biochemistry Module 3
- Institution
- Biochemistry Module 3
PCOL 838A Exam Questions_ Neoplasia (1).
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PCOL 838A Exam Questions: NeoplasiaCyclin-Dependent Kinase Inhibitors - ANS-Evading Growth Suppressors
Immune Activating Anti-CTLA4 mAb - ANS-Avoiding Immune Destruction
Telomerase Inhibitors - ANS-Enabling Replicative Immortality
Selective anti-inflammatory Drugs - ANS-Tumor-Promoting Inflammation
Inhibitors of HGF/c-Met - ANS-Activating Invasion and Metastasis
Inhibitors of VEGF Signaling - ANS-Inducing Angiogenesis
PARP Inhibitors - ANS-Genome Instability and Mutation
Proapoptotic BH3 Mimetics - ANS-Resisting Cell Death
Aerobic Glycolysis Inhibitors - ANS-Deregulating Cellular Energetics
EGFR Inhibitors - ANS-Sustaining Proliferative Signaling
What are the 3 germ layers? - ANS-Ectoderm, Endoderm, and mesoderm
What germ layer(s) is/are associated with the term carcinoma? - ANS-Ectoderm and Endoderm
What germ layer(s) is/are associated with the term sarcoma? - ANS-Mesoderm
True or False: High turnover of epithelial layer means a high prevalence of carcinomas. -
ANS-True
True or False: During infancy mesenchymal tissue are actively dividing meaning there is an
increase in prevalence of sarcomas. - ANS-True
What are the true statements of driver mutations: - ANS-- They are tumor specific
- Can be pan tumor type / common across different tumor types
- Coverts proto-oncogenes to oncogenes
- Inactivates tumor suppressor genes
True or False: All cancers carry somatic mutations. - ANS-True
What are some examples of hyperplasia? - ANS-Eczema and psoriasis
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