Exam (elaborations)
N301 Pharmacology Drexel Ace (1)
N301 Pharmacology Drexel Ace (1)
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N301 Pharmacology Drexel AceWhat is pharmacokinetics? - ANS-study of drug movement through the body
What are the 4 elements of Pharmacokinetics? - ANS-absorption, distribution, metabolism,
excretion
What are the 3 ways a drug can cross a membrane? - ANS-through channels or pores, aided by
a transport system, direct penetration of membrane
What 6 things effect absorption - ANS-Rate kid dissolution, surface area, blood flow, lipid
solubility, pH partioning, route of administration
What is absorption - ANS-Movement of the drug from the site of administration into the blood
Advantages of IV administration? - ANS-Rapid onset, control of level of drug, ability to
administer large volumes of fluid
What is enteral absorption? - ANS-Using GI tract
Advantages of IM administration? - ANS-Good for mess with poor water solubility, used for
depot administrations
Advantages of oral route? - ANS-Easy, convenient, safe
Disadvantages of oral route? - ANS-Variability of absorption
What is chemical equivalence? - ANS-Contains some amount of an identical compound
What is bioavailability? - ANS-2 drugs are equal in bioavailability if they are absorbed at same
rate
What is distribution? - ANS-Movement of drugs throughout the body
What 3 factors effect distribution? - ANS-Blood flow, ability to exit the vascular system, ability of
the drug to enter the cells
What 2 pathologic conditions create low blood flow that affects drug distribution? -
ANS-Abscesses and solid tumors
What 3 ways can drugs exit the vascular system? - ANS-Blood brain barrier, placenta, protein
binding
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