Exam (elaborations)
NUR 2060 - CNS Drugs (1)
- Course
- NR 667 VISE
- Institution
- NR 667 VISE
NUR 2060 - CNS Drugs (1)
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NUR 2060 - CNS Drugslevodopa (Dopar)* - overview - ANS-Dopaminergic Agent
Tx for Parkinson's
Pre-drug converted to DA (decarboxylase) --> increases [DA]
levodopa (Dopar)* - ADRs - ANS-dark sweat/urine
involuntary movements
postural hypotension
N/V --> stim. of CTZ in medulla
confusion
paranoia
visual hallucinations
nightmares
levodopa (Dopar)* - Drug Interactions - ANS-levodopa (Dopar) + MAOIs = HTN
levodopa (Dopar)* - Nursing Implications - ANS-levodopa competes w/ amino acids for
absorption --> teach low protein diet
max effect may take several months
warn pt --> dark urine/sweat
levodopa + carbidopa (Sinemet)* - overview - ANS-dopaminergic agent
drug of choice in Parkinson's
levodopa + carbidopa (Sinemet)* - action - ANS-decreases destruction of peripheral levodopa
via decarboxylase
remember levodopa = precursor to DA
levodopa + carbidopa (Sinement)* - nursing implications - ANS-decreased CTZ stimulation
compared to levodopa (Dopar)
increases stability of symptom control
much smaller dose of levodopa compared to levodopa (Dopar)
,ropinerole (Requip)* - overview - ANS-dopaminergic agent
1st line drug for mild Parkinson's symptoms esp. in younger pts
ropinerole (Requip)* - advantages - ANS-no competition with dietary proteins for absorb.
lowers incidence of dyskinesia
fewer response failures for tx
no need for enzymatic conversions (not a predrug)
ropinerole (Requip)* - ADRs - ANS-Hallucinations
"sleep attacks"
postural hypotension (in combo with Sinemet)
pramipexole (Mirapex) - ANS-dopaminergic agent
1st line drug for mild Parkinson's symptoms esp. in younger pts
used for impulse control
apomorphine (Apokyn) - ANS-dopaminergic agent
1st line drug for mild Parkinson's symptoms esp. in younger pts
Route = Sub Q
bromocriptine (Parlodel) - ANS-dopaminergic agent
1st line drug for mild Parkinson's symptoms esp. in younger pts
entacapone (Comtan)* - action - ANS-COMT inhibitor --> blocks degradation of peripheral
levodopa (precursor to DA) --> increased DA available to brain
Dopaminergic drug for Parkinson's
tolcapone (Tasmar) - ANS-COMT inhibitor
dopaminergic drug for Parkinson's
selegiline (Carbex, Eldepryl)* - action - ANS-MAO inhibitor --> increase [levodopa] --> increases
[DA]
, dopaminergic drug for Parkinson's
selegiline (Carbex, Eldepryl) - nursing implications - ANS-may decrease Parkinson's
progression w/ early use
effectiveness may be brief (1-2 yrs)
rasagiline (Azilect) - ANS-MAO inhibitor
dopaminergic drug for Parkinson's
benztropine (Cogentin)* - action - ANS-Anticholinergic agent --> blocks ACh
drug therapy for Parkinson's
reduce tremor & rigidity (NOT bardykinesia)
benztropine (Cogentin)* - uses - ANS-anticholinergic drug for Parkinson's
early stage Parkinson's
younger Parkinson's pts
benzotropine (Cogentin)* - ADRs - ANS-anticholinergic effects
dry mouth
blurred vision
constipation
trouble urinating
sedation
increased HR
increased Temp
biperiden (Akineton)* - action - ANS-Anticholinergic agent --> blocks ACh
drug therapy for Parkinson's
reduce tremor & rigidity (NOT bardykinesia)
biperiden (Akineton)* - uses - ANS-anticholinergic drug for Parkinson's
early stage Parkinson's
younger Parkinson's pts
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